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OpenTrials
Completed

NCT Number: NCT02429817

Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.

On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.

Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy respiratory function

Exclusion criteria

  • Pulmonary disease

Treatment and study plan

Technetium-99m - Diethylenetriaminepentaacetic acid

Drug

99mTc-DTPA solution placed on the nebulizer reservoir

Aeroneb Solo

Device

Jet Nebulizer

Device

Single Photon Emission Computed Tomography

Other

Imaging technique to investigate lung aerosol distribution

Spirometry

Other

FEV1, FVC assessment

Primary outcomes

  1. Pulmonary deposition

    Time frame: Immediately after nebulization by imaging technique, expected average of 15 minutes

    Single photon emission tomography combined with a CT-scan

Secondary outcomes

  1. Three-dimensional penetration index

    Time frame: immediately after the nebulization by imaging assessment, expected average of 30 minutes

Other outcomes

  1. Spirometry

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Apr 29, 2015
Registry last updated
Dec 5, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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