Skip to main content
OpenTrials
Completed

NCT Number: NCT02812901

Tolerance of Myocardium to Ischemia Injury

This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Reperfusion Injury Cardiovascular Diseases Heart Diseases Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lille University Hospital

Lille, 59000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation
  • Patient in sinus rhythm at the time of surgery
  • Patient older than 18
  • Patient able to understand the information and consent forms

Exclusion criteria

  • Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug
  • left ventricle ejection fraction < 40%
  • Pregnancy
  • Patient in emergency condition

Treatment and study plan

cardiac surgery scheduled in the morning

Procedure

cardiac surgery scheduled in the morning

cardiac surgery scheduled in the afternoon

Procedure

cardiac surgery scheduled in the afternoon

Primary outcomes

  1. ischemia reperfusion injury in ex vivo conditions

    Time frame: the day of the myocardial biopsy

    measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Morning / Afternoon Variation in Myocardial Ischemia Tolerance

Acronym: TOMIS

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jun 24, 2016
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.