Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties

Inclusion criteria

• Male or Female aged 18-65 years old (inclusive)
• Body Mass Index (BMI) 27 - 32kg/m2 (inclusive), measured and defined by the site
• Self-reported stable body weight for the past 6 months prior to screening (defined as not having gained or lost more than 5% of body weight)
• Comfortable using technology, such as a smartphone or laptop
• Willing and able to understand and sign a written informed consent prior to study entry
• Deemed able to comply with the requirements of the study protocol and consume study products by study nurse

Exclusion criteria

• Currently or in the last 3 months, use of medications affecting weight, study outcomes, including fat absorption such as, but not limited to: GLP-1 receptor analogues, SGLT-2 inhibitors, weight loss medications, medications that affect gastric pH, and any of the following drugs: cephaloridine, verapamil, valproic acid, and sulfonylureas, usually acting by competitive inhibition of L-carnitine transport by OCTN2, Orlistat, antacids, proton pump inhibitors, antibiotics, steroids or medications affecting thyroid hormones or gut hormones, antipsychotic medications, or antidepressants. As reported by participant.
• Diagnosed with Eating behaviour disorders such as emotional or restrained eating determined or any ongoing psychiatric illness. As reported by participant.
• Currently or within the last 3 months or planning to during the course of the study being on a weight loss regime (defined by actively following a diet such as Atkins, weight watchers, meal replacements, low or very low carbohydrate diet, ketogenic diet, intermediate fasting or enrolled into a governmental health program) or applying significant restrictions on food intake (i.e., regular breakfast skipping, regular cut on carbohydrates, regular intermittent fasting, diet reducing a specific macronutrient, diet significantly reducing calorie intake, excluding a group of food that was not excluded before). As reported by participant.
• Any known/suspected food allergies. As reported by participant.
• Currently pregnant, lactating, or breastfeeding. As reported by participant.
• Unstable diagnosed chronic conditions (such as hypertension, cardiovascular diseases, liver diseases, renal diseases, metabolic diseases). Unstable is defined as a change in medications in the past 3 months, or a change in disease severity in the past 3 months. As reported by participant.
• Acute GI upset (such as diarrhoea/constipation in the last 2 weeks, abdominal cramping etc.). As reported by participant.
• Diagnosed with chronic GI disorder such as inflammatory bowel disease, Crohn's disease, ulcerative colitis, or irritable bowel syndrome. As reported by participant.
• Ever underwent surgery for weight loss such as bariatric procedures or gastric bypass. As reported by participant.
• Recent blood donation (<8 weeks). As reported by participant.
• Current or past smokers (stopped less than 3 months ago). As reported by participant.
• Any drug abuse within the past year. As reported by participant.
• Alcohol consumption above levels recommended for healthy adults: Average alcohol intake > 2 standard drinks per day over a week for males or > 1 standard drink per day over a week for females as reported by the participant. One standard drink contains 10-12 g of ethanol, i.e., 0.3 dl of strong alcohols, 1dl of wine, 3 dl of beer. As reported by participant.
• Currently participating in another interventional study. As reported by participant.
• Family or hierarchical relationships with the research team members. As reported by participant.