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OpenTrials
Completed

NCT Number: NCT03927989

Tobacco Treatment in the Context of Lung Cancer Screening

The proposed study will test a medication plus text messaging intervention specifically designed for lung cancer screening patients. Half of the patients will receive standard of care, and half will receive the treatment intervention.

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Key information

Age range

55 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

About this study

Screening for lung cancer at earlier, more treatable stages has the potential to reduce mortality from the U.S.'s most deadly cancer. Annual lung cancer screening with low-dose computed tomography is now recommended for high risk individuals based on age and smoking history. This study will evaluate a smoking cessation intervention for lung cancer screening patients. We will evaluate quit rates after a standard intervention (brief counseling session at time of lung cancer screening) versus a dual nicotine replacement therapy (NRT) and gain-framed text messaging intervention.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion:

  • 55 years or older
  • 30 pack year history of smoking
  • current smoker (defined as breath carbon monoxide>6ppm)
  • willing to be randomized
  • English speaking

Exclusion:

  • unstable psychiatric/medical conditions such as suicidal ideation, acute psychosis, severe alcohol dependence, substance abuse, or dementia
  • in the immediate (within 2 weeks) post myocardial infarction period
  • serious arrhythmias
  • unstable angina pectoris
  • hemodynamically or electrically unstable
  • currently taking part in any other tobacco treatment program or using cessation medication (i.e., taking NRT or other cessation medications, enrolled in the Quitline, in another drug study).

Treatment and study plan

Text messaging plus nicotine replacement therapy

Behavioral

Brief advice to quit smoking prior to lung cancer screening (LCS), 8 weeks of gain-framed, LCS-tailored text messages, and nicotine replacement therapy.

Standard Care at Lung Cancer Screening

Other

Brief advice to quit smoking prior to lung cancer screening

Primary outcomes

  1. End of Treatment Abstinence Rates

    Time frame: Week 8 (end of treatment)

    7-day point prevalence abstinence

Secondary outcomes

  1. End of Study Abstinence Rates

    Time frame: 3-month follow-up

    Effect size estimates at End of Study

Sponsors and collaborators

Lead sponsor

Medical University of South Carolina

Other

Registry information

Important dates

Study start
2019
Primary completion
2023
Study completion
2024
First posted
Apr 25, 2019
Registry last updated
Nov 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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