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OpenTrials
Recruiting

NCT Number: NCT05881863

To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation

Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the "laser mode" is activated on the Monsoon jet ventilator. Ventilation is continued during "laser mode."

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Pankhura Gupta

CONTACT

[email protected]

763-268-9823

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.
  • 18 years or older
  • Need rigid bronchoscopy as pre-determined by the interventional pulmonologist

Exclusion criteria

  • Refusal to sign consent
  • Pregnant patients
  • Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm
  • Respiratory instability defined as SpO2<90% with >90% supplemental oxygen.
  • Ineligible for rigid bronchoscopic intubation
  • Latex allergy
  • Evidence of fistulous airway
  • Active Bronchopleural fistula

Treatment and study plan

No intervention

Other

This is an observational study

Primary outcomes

  1. Time in seconds to AiO2 from 90 to 40%

    Time frame: baseline

    Time in seconds to AiO2 from 90 to 40% after activating laser mode on the monsoon jet ventilator.

Secondary outcomes

  1. Differences in time to laser mode AiO2

    Time frame: baseline

    Differences in time to laser mode AiO2 between trachea and left and right mainstem bronchi.

Study contacts

Contact information is provided by the study sponsor or research team.

Candace Nelson

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 31, 2023
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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