To Evaluate the Safety, Tolerability and Pharmacokinetics of K0706 in Plasma and Cerebrospinal Fluid in Healthy Volunteers

Inclusion criteria

• Healthy adult male subjects, 18 to 45 years of age, inclusive, at screening.
• Willing and able to give written, and dated an informed consent.
• Willing and able to comply with the scheduled visits, treatment plan, laboratory testing, study procedures, and restrictions in the Investigator's opinion, and be accessible for follow-up.
• Medically healthy on the basis of medical history and physical examination.
• Subjects enrolled in the study should not father a child and follow the necessary precautionary measure to be taken during the course of the study.

Exclusion criteria

• Subjects with a history of a frequent headache, nausea, or vomiting suggestive of increased intracranial pressure.
• Subject report of recent (6-month) alcohol abuse or illicit drug use or who tests positive at screening, Check-in, or outpatient Visits for breath alcohol and/or drugs of abuse or cotinine;
• Subjects with a history of any relevant allergy/hypersensitivity.
• Subjects determined by the investigator to have any medical condition that could jeopardize their health or prejudice the results.
• Subjects who have participated in CSF collection studies within 56 days prior to check-in.
• Subjects who donated plasma within 14 days prior to the check-in visit.