To Evaluate the Safety, Tolerability, and Pharmacokinetics After Subcutaneous Administration of C1K in Healthy Subjects

Inclusion criteria

• Healthy subjects aged 19 - 45 years at the time of screening visit procedure.
• The subject weighs in the range of 50.0 - 90.0 kg and has a body mass index (BMI) in the range 18-27 kg/m2.
• Sufficient ability to understand the study after being informed about the study and provide written informed consent.
• Based on physical examination, vital sign, 12-lead ECG and laboratory test etc. and in the opinion of the investigator, the subject is suitable for the study.

Exclusion criteria

• A subject with clinically significant hepatobiliary, renal, neurologic, respiratory, endocrine, blood•oncology, cardiovascular, urinary, or, psychical diseases or a history
• A subject who has difficulty with sub-cutaneous injection(ex: tattoo, allergy on skin etc.)
• A subject who has hypersensitivity to the drugs of the drugs containing the same class, or other drugs, or a history of clinically significant hypersensitivity
• A subject who has ventricular tachycardia, ventricular tachycardia, ventricular flutter or confirmed other ventricular flutter and QTc interval: > 450 ms or the other clinically significant medical findings
• A subject with the following results in the screening test:

• Blood AST (GOT), ALT (GPT): > Normal range upper × 1.5
• Blood CPK > Normal range upper × 1.5
• eGFR (CKD-EPI equation) < 60 mL/min/1.73 m2
• Positive serological test (syphilis test, hepatitis B test, hepatitis C test, human immunodeficiency virus (HIV) test)
• A subject with the following results in the screening test:

• systolic blood pressure < 80 mmHg or > 140 mmHg
• diastolic blood pressure < 50 mmHg or > 90 mmHg
• A subject with a history of drug abuse or positive urine screening test for drug abuse
• A subject who administered any prescription drugs or herbal medicine within 2 weeks prior to the expected date of the first dose, or any over-the-counter drug (OTC drug) or vitamin within 1 week prior to the expected date of the first dose (However, can participate in the study if otherwise decided eligible by the investigator).
• A subject who participated in other clinical trial and administered investigational drug within 6 months prior to the expected date of the first dose
• A subject who donated whole blood within 2 months or the component blood within 1 month prior to the expected date of the first dose, or received blood transfusion within 1 month prior to the expected date of the first dose
• Smokers who smoke more than 10 cigarettes/day in the last 3 months as of screening day.
• A subject with persistent alcohol intake (> 21 units/week, 1 unit = 10 g of pure alcohol), or inability to abstain from drinking from 3 days before the expected date of the first dose until the last discharge
• A male subject who has plan to have a baby or to donate sperm. A female subject who is pregnant or lactating or has plan to lactate within 3 months after administration of IP
• A subject who is intending to become pregnant during this study or with inability to use a medically acceptable contraception method(ex. sterilization operation, intrauterine device etc. for Subject or subject's partner

※ medically acceptable contraception method

• Use of intrauterine device which is proven pregnancy failure rates in spouses (or partners).
• Use combined blocking contraceptives (for male or female) and antiseptic drugs
• Subject or partner's operation(vasectomized, bilateral tubal occlusion, hysterectomy)
• Subject who is considered inadequate to participation in the study due to other reason under investigator's discretion