To Evaluate Safety, Tolerability and Pharmacokinetics of GRC 27864 in Healthy Subjects and Elderly Healthy Subjects

Inclusion criteria

• Male or female subjects, aged ≥18 to <55 years (> 65 years for elderly cohort) at the time of informed consent
• Body mass index (BMI) within the range 18.5-32 kg/m2 (inclusive); weight must be >50 kg
• Subjects who are healthy and free from clinically significant illness or disease
• Females must be of non-childbearing potential, surgically sterile.
• Male subjects whose partners are of childbearing potential or have undergone tubal ligation must agree to use 2 highly effective methods of contraception

Exclusion criteria

• Systolic blood pressure (SBP) <90 mmHg or >140 mmHg, diastolic blood pressure (DBP) <45 mmHg or >90 mmHg, resting pulse rate <40 beats per minute (bpm) or >100 bpm
• Subjects who have the presence of active peptic ulcer disease, gastrointestinal (GI) bleeding, chronic gastritis, inflammatory bowel disease, chronic diarrhoea or positive 13C urea breath/faecal test for Helicobacter pylori at Screening.
• Subjects with inherited or acquired disorders of platelet function, bleeding or coagulation.
• Presence of any clinically relevant acute or chronic disease that could interfere with the subject's safety during the clinical study, expose the subject to undue risk.