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OpenTrials
Completed

NCT Number: NCT01842100

To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy

Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when compared to the universal antibiotic prophylaxis strategy.

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Key information

Conditions

Induced Abortion Communicable Diseases Disease Attributes Genital Diseases Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Postaboral Pelvic Inflammatory Disease Sexually Transmitted Diseases Sexually Transmitted Infections Urogenital Diseases

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Queen Mary Hospital

Hong Kong, China

About this study

While universal antibiotic prophylaxis during induced abortion has been proven to reduce postabortal pelvic inflammatory diseases, screen-and-treat approach has the potential benefit of altering women's sexual behavior and preventing further re-infection by sexually transmitted infections. We conducted a randomized controlled trial to compare the effect of the two approaches in preventing postabortal pelvic inflammatory disease and the women's sexual behavior.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women requesting for induced abortion in the gynecology clinic

Exclusion criteria

  • nil

Treatment and study plan

Universal antibiotic prophylaxis

Drug

100 mg twice daily for 7 days starting on the day of induced abortion

Screen-and-treat

Other

Specific antibiotic treatment was only given if the women was found to have sexually transmitted infection(s) on screening.

Primary outcomes

  1. Rate of postabortal inflammatory disease 6 weeks after induced abortion.

    Time frame: 6 weeks after induced abortion.

Secondary outcomes

  1. Rate of re-infection by sexually transmitted infections 24 weeks after induced abortion.

    Time frame: 24 weeks after induced abortion.

  2. Proportion of women having abstinence from sexual intercourse or using condom at 6 weeks, 24 weeks and 1 year after induced abortion.

    Time frame: 6 weeks, 24 weeks and 1 year after induced abortion

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Important dates

Study start
1999
Primary completion
2006
Study completion
2006
First posted
Apr 29, 2013
Registry last updated
Apr 29, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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