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Completed

NCT Number: NCT06789874

To Compare the Efficacy of Intralesional Saline Versus 35% Trichloracetic Acid (TCA) Peel in the Treatment of Atrophic Acne Scars

This study aimed to compare the efficacy of intradermal normal saline versus trichloroacetic acid (TCA) in treating atrophic acne scars. Atrophic acne scars are a common and disfiguring complication, with limited research on the use of normal saline.

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Key information

Conditions

Atrophic Acne Scar Atrophic Acne Scarring

Age range

16 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Sheikh Zayed Medical College/Hospital, Rahimyarkhan, Punjab Province, Pakistan

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About this study

Acne vulgaris is a common skin problem affecting adolescents and adults. It is the eighth most common skin disease globally, having a prevalence ranging from 35%-85%, with notable variations across different regions and age groups.A randomized controlled trial was conducted at the Dermatology Department, Sheikh Zayed Hospital, Rahim Yar Khan, from 1st April 2023 to 31st October 2023. 126 patients were enrolled. Scar grading was based on Goodman and Baron's Qualitative Scar Classification. The Observer Scar Assessment Scale (OSAS) was used by dermatologists. Patients rated their acne scars using the Visual Disease Severity Scale. Photographs were taken for comparison. Efficacy was defined as ≥50% improvement in the OSAS.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 13-50 years
  • Clinically diagnosed patients of atrophic acne scars on face
  • duration of more than 6 months
  • no history of any procedural intervention in past 3 months

Exclusion criteria

  • history of keloid, active acne, local infection, skin allergies, hypertrophic scarring, photosensitivity, or history of any comorbidities
  • history of use of oral isotretinoin, OCPs, steroids or immunosuppressants
  • pregnant or lactating females

Treatment and study plan

Intralesional Saline

Procedure

Intralesional Saline injected in scars

35% trichloracetic acid peel

Procedure

35%Trichloracetic acid peel was applied to scars monthly for 3 months

Primary outcomes

  1. Observer Scar Assessment Scale

    Time frame: clinical assessment will be done monthly for 6 months

    efficacy was labelled as improvement on observer scar assessment scale by >50% compared to baseline. Patient's satisfaction was recorded as 'not satisfied' (VAS score of 1-5), 'Satisfied' (VAS score of 6-7), and 'very satisfied' (Vas score of 8-10)

Sponsors and collaborators

Lead sponsor

Sheikh Zayed Medical College

Other Gov

Registry information

Official study title

Comparing the Efficacy of Intralesional Saline Versus 35% Trichloracetic Acid (TCA) Peel in the Treatment of Atrophic Acne Scars

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jan 23, 2025
Registry last updated
Jan 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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