Tissue-Engineered Construct Based on Amniotic Membrane and Calcium Alginate for Cesarean Section Wound Healing

The amniotic membrane (AM) is a natural biological material with regenerative and anti-inflammatory properties. In this study, a biodegradable tissue-engineered construct (TEC) combining amniotic membrane and calcium alginate is applied to the postoperative wound after cesarean section.

A total of 100 participants will be randomized into two groups:

• Experimental group - TEC application to the postoperative wound.
• Control group - standard postoperative wound care without TEC. Outcomes will include objective ultrasound measures of scar formation, cytokine profile changes, clinical scar evaluation (POSAS), and cosmetic appearance at 12 weeks.

Inclusion criteria

• Women aged 18 years and older.
• Planned elective cesarean section for medical indications (breech presentation, multiple pregnancy, large fetus, uterine scar, etc.).
• Absence of severe obstetric complications (e.g., preeclampsia, hemorrhage, placental abruption).
• No decompensated chronic diseases or acute infections.
• Signed written informed consent.

Exclusion criteria

• Acute infectious, autoimmune, or oncological diseases.
• Severe pregnancy complications (preeclampsia, eclampsia, decompensated gestational diabetes).
• Emergency cesarean section.
• Severe postpartum complications: massive bleeding (>1000 mL), infection, abscess, severe anemia, allergic reactions to dressing materials.
• Withdrawal of consent or inability to continue participation.