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Completed

NCT Number: NCT01179997

Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)

The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width criteria.

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Key information

Conditions

Heart Failure Cardiac Resynchronization Therapy Cardiovascular Diseases Heart Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Hospital Clinic Universitari

Barcelona, Catalonia, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients submitted to de novo implant due to conventional cardiac resynchronization therapy indications.

Exclusion criteria

-

Treatment and study plan

Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves

Device

Electrocardiographic optimization of the interventricular pacing delay according to QRS width

Device

Primary outcomes

  1. 6-month echocardiographic response

    Reduction of the end-systolic volume (measured in mililiters according to transthoracic echocardiography) of >10% as compared to the baseline value.

Secondary outcomes

  1. 6-month clinical response

    Combined end-point consisting in no death due to cardiovascular reasons, no heart transplantation and distance increase of >10% (measured in meters) in the 6-minute walking test.

Sponsors and collaborators

Lead sponsor

Hospital Clinic of Barcelona

Other

Collaborators

  • Fundacio Clinic Barcelona

Registry information

Important dates

First posted
Aug 11, 2010
Registry last updated
Feb 27, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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