Memorial Sloan Kettering Cancer Center
New York, 10065, United States
Completed
NCT Number: NCT02106611
Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors
This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.
Completed
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Notify MeKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center.
- Age ≥ 18 years
- Treatment for HL that included mediastinal RT at initial diagnosis or relapse.
- ≥ 5 years from last HL treatment.
Exclusion criteria
- Primary HL diagnosis prior to 1980.
- Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm.
- Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function [EF < 55%] during prior clinical care).
- Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate <30 ml/min/1.73m^2).
- Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).
Treatment and study plan
Clinical Assessment
OtherHL treatment will be determined by review of available medical records as archived at MSKCC. Recorded variables will include: (1) RT - field, fractional and cumulative dose, and duration; (2) chemotherapy - regimen, planned interval, dose per cycle, and cumulative dosages. Patients will also be asked to complete the FACT-LYM questionnaire and the FACIT Fatigue questionnaire.
Stress cardiac MRI
ProcedureBoth imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.
Stress Echocardiogram
ProcedureBoth imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.
Primary outcomes
-
compare the prevalence of cardiac injury
Time frame: 2 years
detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors.
Sponsors and collaborators
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Collaborators
- Weill Medical College of Cornell University
Registry information
Important dates
- Study start
- 2014
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Apr 8, 2014
- Registry last updated
- Feb 11, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.