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Completed

NCT Number: NCT07268235

Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

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Key information

Conditions

Microdissection Testicular Sperm Extraction Azoospermia, Nonobstructive Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Oligospermia Urogenital Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

Clinique ovo

Montreal, Quebec, H4P 2S4, Canada

About this study

This retrospective study evaluates patients undergoing ICSI following micro-TESE. Participants are assigned to two groups based on the interval between sperm extraction and oocyte retrieval (24 vs. 48 hours). Clinical and embryological outcomes from the first embryo transfer will be assessed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
  • Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
  • Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
  • Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

Exclusion criteria

  • Patients who did not have any sperm noted following micro-TESE
  • Use of donor sperm or oocytes
  • Frozen sperm or oocytes
  • Same day oocyte retrieval and sperm extraction
  • Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

Treatment and study plan

Primary outcomes

  1. Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval

    Time frame: For IVF performed from June 2015 to January 2025

Secondary outcomes

  1. Percentage of fertilized oocytes with two pronuclei (2PN)

    Time frame: For IVF performed from June 2015 to January 2025

  2. Percentage of usable blastocyst (defined as frozen and transferred blastocysts)

    Time frame: For IVF performed from June 2015 to January 2025

  3. Pregnancy rate based on positive β-hCG

    Time frame: For IVF performed from June 2015 to January 2025

Sponsors and collaborators

Lead sponsor

Clinique Ovo

Industry

Registry information

Official study title

Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction: Does it Make a Difference? A Single-center Retrospective Cohort

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Dec 5, 2025
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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