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NCT Number: NCT06549322

Timing and Resistance Exercise: Impact on Eating and Metabolism

Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.

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Key information

Age range

20 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, 106, Taiwan

Location contact

Hung Wen Liu, Ph.D.

CONTACT

+886 0277496863

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 20-30
  • weight stable for at least 6 months

Exclusion criteria

  • Obesity (BMI > 30 kg/m² or body fat percentage > 25%)
  • Hypertension (blood pressure over 140/90 mmHg)
  • Heart disease
  • Cancer
  • Liver or kidney diseases
  • Any other conditions that could potentially influence the study's outcomes

Treatment and study plan

The exercise in morning

Other

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets.

Exercise timing: AM 11:00-11:30

The exercise in evening

Other

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets.

Exercise timing: PM 05:00-05:30

Primary outcomes

  1. Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite

    Time frame: 3 hours during each study intervention

    The appetite perceptions are obtained through a 0-100 mm visual analog scale. The variables assessed include perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".

  2. Change in acyl-Ghrelin

    Time frame: 3 hours during each study intervention

    acyl-Ghrelin in pg/mL

  3. Change in PYY

    Time frame: 3 hours during each study intervention

    PYY in pg/mL

  4. Change in Leptin

    Time frame: 3 hours during each study intervention

    Leptin in pg/mL

  5. Change in lactate

    Time frame: 3 hours during each study intervention

    lactate in mmol/L

  6. Change in PBMCs circadian rhythm genes

    Time frame: 3 hours during each study intervention

    Circadian rhythm genes in PBMC will be measured, such as Bmal1, Clock, Per1, Per2, Per3, Cry1, Cry2, Cry3, and Tbp in arbitrary units.

  7. Energy intake

    Time frame: The Before day, the durning day, and the day following the experiment.

    Participants will be required to record their diet for the day before, the current day, and the day following the experiment.

    The energy intake include absolute energy intake and relative energy intake .

  8. Energy expenditure

    Time frame: The Before day, the durning day, and the day following the experiment.

    Participants will record energy expenditure during resistance exercise, with non-exercise energy expenditure measured using an accelerometer.

Secondary outcomes

  1. Explicit liking

    Time frame: 3 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm is utilized to evaluate the question, "How pleasant would it be to taste some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  2. Explicit wanting

    Time frame: 3 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm is utilized to evaluate the question, "How much do you want some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  3. Implicit wanting

    Time frame: 3 hours during each study intervention

    Participants are given a set of food image pairs and are asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The implicit wanting calculation involves further consideration of response time data based on preference choices using a standardized equation.

  4. Relative preference

    Time frame: 3 hours during each study intervention

    Participants are given a set of food image pairs and are asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The relative preference is the sum of the times each type of food is chosen, with a maximum value of 48 and a minimum value of 0.

  5. Taste appeal bias

    Time frame: 3 hours during each study intervention

    Taste preference (savoury or sweet) is calculated by subtracting the mean savory scores from the mean sweet scores. Positive values suggest a preference for sweet foods, while negative scores indicate a preference for savory foods, and a score of 0 signifies an equal preference between taste categories.

  6. Fat appeal bias

    Time frame: 3 hours during each study intervention

    Fat preference (high or low) is calculated by subtracting the mean low-fat scores from the mean high-fat scores. Positive values suggest a preference for high-fat foods, while negative scores indicate a preference for low-fat or savory foods, and a score of 0 signifies an equal preference between fat content.

  7. change in Cortisol

    Time frame: 3 hours during each study intervention

    Cortisol mcg/dL

  8. change in complete blood count

    Time frame: 3 hours during each study intervention

    change in complete blood count cells/L

  9. change in growth hormone

    Time frame: 3 hours during each study intervention

    growth hormone pmol/L

Study contacts

Contact information is provided by the study sponsor or research team.

Hung-wen Liu, Ph.D.

CONTACT

[email protected]

+886 0277496863

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

The Efficacy of Exercise Timing - Effects of Resistance Exercise on Eating Behavior and Energy Metabolism

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 12, 2024
Registry last updated
Aug 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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