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NCT Number: NCT06216964

Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: a Prospective Cohort Study

The aim of this study is to evaluate the negativation time of chlamydial and gonococcal PCRs after treatment for urogenital, oropharyngeal and anal infections.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service du Trait d'Union

Strasbourg, 67000, France

Location status: Recruiting

Location contact

Axel URSENBACH, MD

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • - Patients attending the Trait d'Union department at the Nouvel Hôpital Civil for PrEP consultations, AES or HIV infection.
  • Over 18 years of age
  • Male or female
  • Who have had an uncomplicated CT and/or NG infection treated with currently recommended therapies (Ceftriaxone 500mg DU for NG infections, Doxycycline 200mg per day for 1 week for rectal CT infections and Azithromycin 1g DU or Doxycycline 7 days for other CT infections).
  • Subject affiliated to a social health insurance scheme
  • Subject able to understand the aims and risks of the research and to give dated and signed informed consent

Exclusion criteria

  • - Complicated CT and/or NG infections: epididymitis, prostatitis, upper genital infection, extra-genital involvement (keratoconjunctivitis, arthritis, skin involvement, Fiessinger-Leroy-reiter syndrome, Fitz-Hugh-Curtis syndrome).
  • Interfering treatments and associated diseases: Severe immunosuppression (HIV infection with CD4 less than 200/mm3, chemotherapy in the last 6 months, active haemopathy, congenital immune deficiency, immunosuppressive treatment including corticosteroid therapy for more than 4 weeks or organ transplant.
  • Impossibility of giving the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.).
  • Subject under court protection
  • Subject under guardianship or curatorship

Treatment and study plan

Chlamydia trachomatis (CT) and/or Neisseria gonorrhoeae (NG) NAAT(s)

Diagnostic Test

Test every week after the start of treatment, until NAAT negativation and up to a maximum of 4 weeks

Primary outcomes

  1. Estimate the rate of negativation of NAATs performed at the various sites of CT infection

    Time frame: 4 weeks after initiation of treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Axel Ursenbach, MD

CONTACT

[email protected]

0033.88.15.13.52

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: DECHLAGO

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jan 22, 2024
Registry last updated
Aug 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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