Time-specific Exercise in Circadian Context

The main aim of the project is to examine the effect of as well as of the three-month, timely specific training intervention on the functionality of circadian organization in elderly volunteers. The additive aim is to examine the effect of lifelong endurance physical activity, along with the experimental training intervention on the body composition, bone density, and selected hormonal, biochemical, histological and molecular indicators of metabolic health.

Partial aims are as follows:n to explore the effect of morning and afternoon training on the most significant parameters, identified by the previous cross-sectional study, in sedentary elderly. Furthermore, to clarify adaptation mechanisms of experimental training protocol on selected parameters, that may explain possible differences in mechanisms of active and passive aging.

Inclusion criteria

• no history of regular physical activity training and exercise of more than 150 minutes of moderate or 75 minutes of higher intensity per week.
• Body mass index (BMI) between 18.5 and 30 kg/m2 for all groups

Exclusion criteria

for probands will be:

• Recent or current infection, physical disability,
• malignant, cardiovascular, metabolic, autoimmune diseases,
• Malnutrition and pharmacological interference (e.g., steroids, non-steroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs).

Use of performance enhancing drugs in the past and during the study period will condition exclusion.

Exclusion criteria

• recent or current infection, physical disabilities,
• malignant, cardiovascular, metabolic, autoimmune diseases,
• Malnutrition and pharmacological interference (e.g., steroids, nonsteroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs).

Use of performance-enhancing drugs in the past and during the study period will condition exclusion.