UC Davis, Western Human Nutrition Research Center
Davis, California, 95616, United States
NCT Number: NCT03569852
This is a cross-over intervention study designed to evaluate how four weeks of time restricted feeding (16 hours fasting and 8 hours feeding), compared to four weeks of a more traditional eating pattern (12 hours fasting and 12 hours feeding), affects resting energy expenditure, subjective and biochemical markers of satiety and hunger, body composition, cardiovascular health, substrate utilization and fitness in male competitive runners.
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Notify Me20 year–40 year
Male
Interventional
Not applicable
Davis, California, 95616, United States
Weight loss and improvements in body composition (increasing muscle mass and decreasing fat mass) are common goals for both dieters and athletes. Although a traditional method of achieving this has been accomplished through caloric restriction, an alternate method that is becoming increasingly popular is fasting. Fasting is described as the absence of food and/or calorie-containing beverage consumption for a period of time. The majority of people fast for 8-10 hours daily, which occurs during the overnight period when people are asleep Intermittent fasting, specifically time-restricted feeding (TRF), has recently gained popularity because it is a more sustainable means of practicing fasting and it has been shown to enhance the loss of fat mass with or without caloric restriction. It has also been shown to enhance overall health due to reports of reduced fasting glucose, insulin resistance, triglycerides, and reduced total and low-density lipoprotein (LDL) cholesterol levels in obese women. Despite its growing popularity among athletes, there is scarce research on how adhering to this type of diet pattern affects athletic performance and other biochemical markers related to health. The participants in this study will be randomly assigned to either a traditional (12/12) or a time restrictive (16/8) eating pattern in a crossover design. Each pattern will last for four weeks with a minimum two week washout in between, and the participants will consume the same calorie and macronutrient amounts based on recommendations made by the American College of Sports Medicine (ACSM) for both eating patterns. The 12/12 pattern will require subjects to consume 5 meals (breakfast, lunch, dinner, and two snacks) per day within a 12 hour period suggested to be around 8am, 10am, 12pm, 3pm, and 7pm. The 16/8 pattern will require subjects to consume 3 meals in an 8-hour period suggested to be around 12pm, 3pm, and 7pm. Subjects may only consume water, unsweetened coffee, or unsweetened tea (no artificial sweeteners) during their periods of fasting. Subjects will perform all exercise in the morning before 8 am in the fasted state. Subjects will visit the Western Human Nutrition Research Center (WHNRC) for test days at baseline (study day 1), after four weeks of the first dietary intervention (study day 28), and at the start (study day 43) and end of the second dietary intervention (study day 70), for a total of 4 test days over the duration of 10 weeks.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Volunteers will adhere to a form of time restrictive feeding, 16 hours fasting and 8 hours eating per day.
Other names: Intermittent Fasting
Volunteers will adhere to a more traditional eating pattern, 12 hours fasted and 12 hours eating per day.
Other names: Normal Diet
Time frame: Study day 1, 28, 43 and 70
Resting energy expenditure will be measured using a metabolic cart
Time frame: Study day 1, 28, 43 and 70
Body composition, including fat mass and lean body mass, will be measured by dual-energy x-ray absorptiometry (DEXA) and expressed in kilograms (kg).
Time frame: Study day 1, 28, 43 and 70
Carbohydrate and fat utilized for energy will be measured using a metabolic cart
Time frame: Study day 1, 28, 43 and 70
Time to run a 10 kilometer time trial on a treadmill expressed in minutes
Time frame: Study day 1, 28, 43 and 70
Perceived hunger and fullness will be measured using a visual analog scale. Responses will be a mark on an unsegmented line from 0 or "not at all" to 5 or "extremely."
Time frame: Study day 1, 28, 43 and 70
Fasting plasma will be analyzed for glucagon (pmol/L) as measured by enzyme-linked immunoabsorbant assay
Time frame: Study day 1, 28, 43 and 70
Fasting plasma will be analyzed for leptin (pmol/L) as measured by enzyme-linked immunoabsorbant assay
Time frame: Study day 1, 28, 43 and 70
Fasting plasma will be analyzed for ghrelin (pmol/L) as measured by enzyme-linked immunoabsorbant assay
Time frame: Study day 1, 28, 43 and 70
Fasting plasma will be analyzed for insulin (pmol/L) as measured by enzyme-linked immunoabsorbant assay
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for total cholesterol (mmol/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for HDL cholesterol (mmol/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for LDL cholesterol (mmol/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for very low-density lipoprotein (VLDL) cholesterol (mmol/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for triglycerides (mmol/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for alanine aminotransferase (IU/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for aspartate aminotransferase (IU/L) by Piccolo analyzer
Time frame: Study day 1, 28, 43 and 70
Fasting serum will be analyzed for glucose (mmol/L) by Piccolo analyzer
USDA, Western Human Nutrition Research Center
Fed
The Effects of Four Weeks of Intermittent Fasting on Resting Energy Expenditure, Satiety Hormones, Body Composition, and Performance in Competitive Runners
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