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NCT Number: NCT06366113

Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.

The program should not be improved by introducing new subjects such as circadian rhythm.

Recruiting

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Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinique la Mitterie

Lille, 59130, France

Location status: Recruiting

Location contact

Michaël RACODON, PhD

CONTACT

[email protected]

+33320223457

About this study

Respiratory diseases are a leading cause of death in developed countries. To avoid complications and recurrences, secondary prevention in patients with respiratory diseases is essential. Pulmonary rehabilitation (PR) is a well-established and effective treatment that is supervised by medical professionals and conducted in dedicated centres. It has been shown to reduce hospital readmissions, secondary events, and patient mortality.

The timing of reconditioning is crucial. Previous studies have indicated that training times affect strength and power gains. Additionally, the time of day for training can significantly impact progress in aerobic capacity.

Disturbances to the biological clock can have consequences for people with respiratory pathologies, particularly an alteration in muscular function.

Therefore, studying the temporal specificity of exercise re-training in patients with respiratory diseases is of interest.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Patient with chronic obstructive pulmonary disease (COPD)
  • Registered for respiratory re-education and rehabilitation at the Clinique de la Mitterie
  • Number of rehabilitation sessions at least 18 over 4 weeks
  • Written informed consent signed by the patient
  • Membership of a social security

Exclusion criteria

  • - cardiovascular contraindications to exercise
  • unstable respiratory status (uncompensated respiratory acidosis)
  • conditions interfering with the pulmonary rehabilitation process (progressive neuromuscular disease, psychiatric illness)

Treatment and study plan

Pulmonary Rehabilitation

Other

Pulmonary rehabilitation includes :

  • Exercise re-training with resumption of physical activities
  • therapeutic patient education

Primary outcomes

  1. 6-minute walk test (6MWT)

    Time frame: 15 minutes

    Walking distance in a test

Secondary outcomes

  1. Time limit test (Time-lim)

    Time frame: 0 to 900 secondes

    Endurance exercise holding time in seconds

  2. Sit to stand test (STT)

    Time frame: 1 minute

    The number of sit-to-stand repetitions during the test.

  3. Single arm curl Test (SAC)

    Time frame: 1 minute

    The number of bends during the test

  4. Single-leg stance test (SLT)

    Time frame: 1 minute

    The time for balance

  5. Hospital Anxiety and Depression Scale (HAD)

    Time frame: 10 minutes. The maximum mark for each score is 21 and the minimum mark is 0. The higher the score, the more depressed or anxious the person.

    Hospital Anxiety and Depression score

  6. Pittsburgh Sleep Quality Index

    Time frame: 10 minutes. The total score ranges from 0 to 21, with 0 indicating no difficulties and 21 indicating major difficulties.

    Sleep quality score

Study contacts

Contact information is provided by the study sponsor or research team.

Michaël RACODON, PhD

CONTACT

[email protected]

+33320223457

Sponsors and collaborators

Lead sponsor

Michaël RACODON

Other

Registry information

Official study title

Effect of Time of Exercise Re-training on Functional Capacity in Individuals With Chronic Obstructive Pulmonary Disease (COPD)

Acronym: CHRONOBIO

Important dates

Study start
2024
Primary completion
2024
Study completion
2026
First posted
Apr 15, 2024
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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