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Completed

NCT Number: NCT06786273

Time Course of Endometrium's Gene Expression Profiles Using Endometrial Tissue and Blood Samples

This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.

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Key information

Conditions

Fertility

Age range

25 year–38 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

Lee Women's Hospital

Taichung, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Regular menstrual cycle of 28-32 days.
  • Between 25-38 years old.
  • BMI between 18 to 30.
  • Endogenous progesterone (P4) level of < 1 ng/mL prior to exogenous progesterone administration

Exclusion criteria

  • Suspected intrauterine abnormality.
  • Women who are breastfeeding
  • Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases.
  • History of major illness.
  • Use of hormonal contraceptives or intrauterine devices in the past 3 months.

Treatment and study plan

Small RNA sequencing

Genetic

The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Primary outcomes

  1. miRNA expression profiles

    Time frame: 1 month

    The samples collected would undergo small RNA sequencing in order to investigate the miRNA expression profiles of the patients and differences in expression profiles between the different intervention groups.

Sponsors and collaborators

Lead sponsor

Inti Labs

Industry

Registry information

Official study title

Time Course of Endometrium's Gene Expression and DNA Methylation Profiles Using Endometrial Tissue and Blood Samples

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 22, 2025
Registry last updated
Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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