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NCT Number: NCT07207863

Tianshan Community Cohort Establishment and Follow-up

This population-based cohort study on disease prevention and health promotion was established in northwest China, leveraging data from routine annual health examinations. Initiated in January 2016, the cohort enrolled nearly all residents aged 18 years and older who were registered at community healthcare centers. The program was developed to provide a comprehensive framework for disease prevention and community health promotion, with the aim of producing population-based evidence across a broad spectrum of diseases in the general population. At baseline, data were collected on participant demographics, medical and family histories, disability status, living environment, and blood biochemical parameters. Follow-up information is primarily obtained through chronic disease management programs, annual health examinations, and electrical health records. Cause-specific mortality is ascertained from local death registration systems. Biological specimens, questionnaire data, and electrical health records are systematically archived in the Biobank and Big Data Center of the People's Hospital of Xinjiang Uygur Autonomous Region.

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Key information

Conditions

Cohort Study Natural Population Northwest Region of China

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

People's Hospital of Xinjiang Uygur Autonomous Region

Ürümqi, Xinjiang, 830001, China

Location status: Recruiting

Location contact

Qian Zhao, Dr.

CONTACT

[email protected]

+8613899993630

Yining Yang, Prof.

PRINCIPAL_INVESTIGATOR

About this study

This research is conducted through population-based health examinations among residents in northwest China. By providing annual health assessments, structured health education, and community-based health promotion activities, the study aims to enhance health awareness, identify determinants of disease, implement targeted interventions to improve lifestyle behaviors, reduce modifiable risk factors, and promote overall community health.

The cohort integrates data from multiple sources- including health assessments, electronic health records, mortality registries, statistical yearbooks, and environmental datasets- encompassing a wide range of health-related information, such as demographics, lifestyle factors, family and personal medical histories, living conditions, enrollment in national public health services, physical examinations, laboratory tests, diagnostic assessments, disease outcomes, and cause-specific mortality. Event-driven follow-up data are obtained from 163 hospitals and 63 Traditional Chinese Medicine hospitals, covering all secondary and tertiary-level hospitals in the region. Inpatient data are systematically documented by qualified medical personnel and entered into an electronic health information system. All disease diagnoses are coded according to the 10th Revision of the International Classification of Diseases (ICD-10). Mortality data, including the timing and specific cause of death, are primarily obtained through local death registration systems.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Residents >=18y
  • Permanent residents or individuals who have lived in the region for more than 5 years and are enrolled in local social security medical insurance
  • Residents without severe physical disability and capable of normal communication
  • Residents whose diseases and deaths are monitored and managed by the local health authorities
  • Residents who voluntarily participate and provide written informed consent

Exclusion criteria

  • Temporary residents or floating population
  • Residents with severe health conditions that prevent participation in the study
  • Residents who are unwilling to undergo follow-up assessments for the study

Treatment and study plan

Primary outcomes

  1. Mortality

    Time frame: 20 years

    All-cause and cause-specific mortality during follow-up

  2. Cardiovascular diseases

    Time frame: 20 years

    Incident disease during follow-up

  3. Digestive diseases

    Time frame: 20 years

    Incident disease during follow-up

  4. Endocrine diseases

    Time frame: 20 years

    Incident disease during follow-up

  5. Infections diseases

    Time frame: 20 years

    Incident disease during follow-up

  6. Benign neoplasm or Carcinoma in situ

    Time frame: 20 years

    Incident disease during follow-up

  7. Cancers

    Time frame: 20 years

    Incident disease during follow-up

  8. Genitourinary diseases

    Time frame: 20 years

    Incident disease during follow-up

  9. Haematological or immunological diseases

    Time frame: 20 years

    Incident disease during follow-up

  10. Musculoskeletal diseases

    Time frame: 20 years

    Incident disease during follow-up

  11. Neurological diseases

    Time frame: 20 years

    Incident disease during follow-up

  12. Psychiatric diseases

    Time frame: 20 years

    Incident disease during follow-up

  13. Respiratory diseases

    Time frame: 20 years

    Incident disease during follow-up

  14. Ocular diseases

    Time frame: 20 years

    Incident disease during follow-up

  15. Dermatological diseases

    Time frame: 20 years

    Incident disease during follow-up

  16. Ear and mastoid disorders

    Time frame: 20 years

    Incident disease during follow-up

Study contacts

Contact information is provided by the study sponsor or research team.

Qian Zhao, Dr.

CONTACT

[email protected]

+86-13899993630

Sponsors and collaborators

Lead sponsor

People's Hospital of Xinjiang Uygur Autonomous Region

Other

Collaborators

  • Karamay Central Hospital of Xinjiang
  • Luopu County People's Hospital of Hotan Prefecture
  • People's Hospital of Altay Prefecture
  • People's Hospital of Hotan Prefecture
  • People's Hospital of Kizilsu Kyrgyz Autonomous Prefecture
  • RenJi Hospital
  • The First People's Hospital of Aksu Prefecture
  • The Second People's Hospital of Kashgar Prefecture

Registry information

Official study title

The Cardiac and Panvascular Medicine Diagnosis and Treatment Center, People's Hospital of Xinjiang Uygur Autonomous Region,

Important dates

Study start
2016
Primary completion
2035
Study completion
2035
First posted
Oct 6, 2025
Registry last updated
Oct 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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