Thyroid Uptake Quantification Validation on a Three-dimensional (3D) Cadmium-Zinc-Telluride (CZT) New Generation Gamma Camera

Thyroid scintigraphy using technetium-99m (99mTc) pertechnetate is traditionally performed using planar imaging to estimate thyroid uptake. Recent developments in quantitative SPECT/CT allow direct activity quantification from three-dimensional tomographic acquisitions. The aim of this study was to evaluate the accuracy of thyroid uptake quantification obtained from 3D SPECT/CT compared with conventional planar image.

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Key information

Conditions

Hypo or Hyperthyroidism Endocrine System Diseases Hyperthyroidism Thyroid Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Princesse Grace

Monaco, 98000

About this study

Planar and SPECT/CT scintigraphy will be performed on a new generation 3D CZT gamma camera and thyroid uptake (TU) value will be calculated on planar acquisition for 27 consecutive patients referred in the department of the investigators for hyper or hypothyroidism.

With a quantitative approach using attenuation, scatter correction and iterative algorithm (12 iterations and 8 subsets) with post filter Median Full Width at Half Maximum (FWHM=3), the TU value with SPECT or SPECT/CT acquisitions can be calculate.

The objective will be to evaluate the potential of a new 3D CZT gamma camera to estimate the thyroid uptake on SPECT (Tomography without attenuation correction) and SPECT/CT (tomography with attenuation correction) acquisitions compared with standard planar scintigraphy as a gold standard.

To established this study it will be necessary to introduce cross-calibration factors performed from homogeneous phantoms, for planar and 3D SPECT acquisitions, to estimate the thyroid uptake values.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

hypothyroidism
hyperthyroidism

Exclusion criteria

Pregnant women

Treatment and study plan

No Intervention: Observational Cohort

Other

Planar and SPECT/CT acquisitions

Primary outcomes

Quantification of thyroid uptake on a 3D CZT gamma camera

Time frame: Day 1

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Princesse Grace

Other

Registry information

Official study title

Clinical Evaluation of Thyroid Uptake Quantification With Technetium-99m (99mTc)-Pertechnetate: Comparison Between Gold Standard Planar and Quantitative 3D CZT Single Photon Emission Computed Tomography/Cumputed Tomography (SPECT/CT) Scintigraphy

Acronym: QThy2Dvc3D

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: May 28, 2026
Registry last updated: May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed