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Enrolling by Invitation

NCT Number: NCT06810752

Thyme Honey for Management of Oral Lichen Planus

the study aimed to assess the effect of topical application of thyme honey in comparison to 0.1% triamcinolone acetonide oral paste on the relief of pain and clinical improvement in patients with OLP

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Key information

Conditions

Oral Lichen Planus Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

The British university in Egypt

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Patients clinically and histopathologically (if required) diagnosed as suffering from OLP.

  • Patients free from any visible oral lesions other than OLP.
  • Patients who agreed to take supplied medications.
  • Patients who agreed for the biopsy (when required).

Exclusion criteria

• •Patients suffering from any systemic disease.

  • Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
  • Treatment with any oral topical medications for at least four weeks prior to the study.
  • Pregnant and lactating women.
  • In addition, no consideration was given to patients with a history of hypersensitivity to honey.

Treatment and study plan

thyme honey

Dietary Supplement

Topical application on the oral mucosa

Triamcinolone Acetonide

Drug

Topical application on the oral mucosa

Primary outcomes

  1. VAS score assessement

    Time frame: 1 month

    Pain intensity

Secondary outcomes

  1. measurement of salivary level of miRna155

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

British University In Egypt

Other

Registry information

Official study title

Thyme Honey for Management of Oral Lichen Planus: A Non- Inferiority Controlled Randomized Clinical Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 6, 2025
Registry last updated
Feb 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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