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NCT Number: NCT01093404

Thrombus Aspiration in Myocardial Infarction

Treatment of myocardial infarction (blood clot in the arteries of the heart) has improved after introduction of 24/7 balloon angioplasty to open the blocked artery. However, the clot itself is not routinely removed but recent data in smaller trials indicate that this might improve recovery and prognosis. In this multicenter study of 5000 patients referred to Scandinavian hospitals for myocardial infarction the investigators test the hypothesis that patients randomized to treatment with thrombus aspiration (removing the blood clot by manual suction) before conventional angioplasty will have a reduced risk of death, fewer rehospitalisations, fewer new myocardial infarctions, reduced risk of heart failure, better coronary artery flow after angioplasty and greater reduction of infarct size compared to patients randomized to conventional angioplasty alone.

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Key information

Conditions

Acute Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a diagnosis of ST-segment elevation myocardial infarction
  • Correspondence between ECG findings and culprit artery pathoanatomy
  • A minimum of 50% stenosis in culprit artery by visual estimate
  • Possibility to perform thrombus aspiration

Exclusion criteria

  • Need for emergency coronary artery bypass grafting
  • Inability to provide informed consent
  • Age below 18 years
  • Previous randomization in the TASTE trial

Treatment and study plan

Thrombus Aspiration

Procedure

Aspiration of thrombus material before angioplasty

Primary outcomes

  1. All-cause death

    Time frame: 30 days

    Death from any cause will be registered via national registries during the first 30 days after study inclusion.

Secondary outcomes

  1. Time to re-hospitalization with nonfatal reinfarction, heart failure and target vessel revascularization

    Time frame: 30 days to 10 years

  2. Time to all-cause death or new myocardial infarction (first occurring) or in hospital treatment for heart failure

    Time frame: 30 days to 10 years

  3. Time to acute coronary occlusion, stent thrombosis and restenosis in treated lesions

    Time frame: 1 year

  4. Length of hospital stay

    Time frame: 1 month

  5. TIMI-flow grade

    Time frame: 3 hours

    TIMI-flow, or Thrombolysis in Myocardial Infarction grading of flow is a semiquantitative method to assess coronary artery flow following balloon angioplasty.

  6. All-cause death

    Time frame: 1 year to 10 years

Sponsors and collaborators

Lead sponsor

Region Örebro County

Other

Collaborators

  • Uppsala University

Registry information

Official study title

Thrombus Aspiration in ST- Elevation Myocardial Infarction in Scandinavia

Acronym: TASTE

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Mar 25, 2010
Registry last updated
Jul 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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