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Recruiting

NCT Number: NCT07043413

Thrombus Analysis of Ischemic Stroke

Patients with acute ischemic stroke who have undergone endovascular thrombectomy will be eligible to be included, and thrombus will be collected after obtaining informed consent. Enrolled patients will receive a comprehensive diagnostic evaluation and the best medical treatment according to recent stroke management guidelines. The mechanism of the stroke will be classified into atherosclerotic, cardiac embolism, others and unknown causes based on diagnostic workup. Patients will be monitored in an outpatient clinic for vascular events including stroke recurrence, death, and bleeding events, which will continue for up to two years after the initial stroke event. Thrombus information related to RNA expression patterns and histological characteristics will be analyzed to classify the stroke mechanism and predict future vascular events after the initial stroke.

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Key information

Conditions

Cerebral Infarction Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Embolism and Thrombosis Infarction Ischemia Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Thrombosis Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, Jong-ro Gu, 03080, South Korea

Location status: Recruiting

Location contact

Jeong-Min Kim, Professor

CONTACT

[email protected]

82-2-2072-4901

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with acute ischemic stroke who had undergone endovascular thrombectomy

Exclusion criteria

-

Treatment and study plan

thrombus analysis

Diagnostic Test

Detailed expression pattern of RNA and histological characteristics will be investigated.

Primary outcomes

  1. Vascular events

    Time frame: two years after initial stroke

    major vascular events after endovascular thrombectomy, including stroke, myocardial infarction, and vascular death

Secondary outcomes

  1. Thromboembolic events

    Time frame: two years after initial stroke

    Any thromboembolic events after endovascular thrombectomy including ischemic stroke, transient ischemic attack, myocardial infarction or unstable angina, peripheral artery disease requiring hospitalization, venous thromboembolism, pulmonary embolism and vascular death

Other outcomes

  1. overall mortality

    Time frame: two years after initial stroke

    any death event after endovascular thrombectomy

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Acronym: TAOIST

Important dates

Study start
2022
Primary completion
2028
Study completion
2029
First posted
Jun 29, 2025
Registry last updated
Jun 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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