Skip to main content
OpenTrials
Completed

NCT Number: NCT04688879

Thrombolysis With Intra-arterial Urokinase

Patients with acute superior mesenteric artery (SMA) occlusion were included in this study. The clinical presentation and effect of the recanalization of the SMA was analyzed on follow-up angiography.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Arterial Occlusion Mesenteric Artery Superior

Sex eligibility

All sexes

Study type

Observational

Primary location

Chang Gung memorial Hospital

Taoyuan City, 886, Taiwan

About this study

Thirteen patients with acute SMA occlusion who underwent intra-arterial urokinase thrombolysis between 2008 and 2020 were retrospectively evaluated.

Clinically, the abdominal pain and the effect of the SMA on angiography will be compared in response and non-response groups.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of SMA occlusion

Exclusion criteria

  • shock in the triage screening
  • peritonitis
  • 3. intramural gas, mesenteric or portal venous gas on contrast-enhanced abdominal CT

Treatment and study plan

intra-arterial urokinase thrombolysis

Procedure

Under local anaesthesia, the right femoral artery was punctured in accordance with the Seldinger technique, and a 6-Fr sheath, 10 cm in length, was implanted. Selective catheterization of the SMA was performed with 4-Fr catheter. The SMA angiography was performed to identify the filling defect. Thrombolysis was performed using a 5-Fr multiple-sideport infusion catheter (100cm with sideport of 7cm, 14 ports or 100cm with sideport of 15cm, 30 ports, Cook, Bloomington, IN, U.S.A). The tip of the microcatheter was embedded in the thromboembolism, which was fragmented at the time of thrombolysis. Thrombolysis was performed locally in the SMA with a bolus of urokinase

Primary outcomes

  1. Thrombolysis with intra-arterial urokinase for acute superior mesenteric artery occlusion: Outcome analysis

    Time frame: Daily series follow-up angiography in the next 72 hours after thrombolysis with intra-arterial urokinase.

    Degree of patency and appearance of the SMA will be analyzed in the follow-up angiography.

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Registry information

Official study title

Thrombolysis With Intra-arterial Urokinase for Acute Superior Mesenteric Artery Occlusion: Outcome Analysis

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Dec 30, 2020
Registry last updated
Dec 30, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.