Skip to main content
OpenTrials
Completed

NCT Number: NCT02552407

Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis

During primary percutaneous coronary intervention, distal embolization of thrombus and impaired microvascular perfusion has been associated with an increased mortality. Thrombectomy devices during primary percutaneous coronary intervention may prevent distal embolization by reducing thrombus burden and thus improve microvascular perfusion and reduce mortality.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Myocardial Infarction Acute Coronary Syndrome Acute Coronary Syndromes Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

An individual patient meta-analysis of large randomized controlled trials comparing manual thrombectomy versus percutaneous coronary intervention alone in patients with ST elevation myocardial infarction will provide significantly more power to detect differences in mortality as well as important but rare events such as stroke and to assess benefits in pre-defined subgroups.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Randomized controlled trials comparing manual thrombectomy vs. percutaneous coronary intervention alone in patients with ST elevation myocardial infarction published between January 1980 and April 2015.
  • Large trials randomizing more than 1000 patients.
  • Trials must have had at least 30 day follow up.

Exclusion criteria

-

Treatment and study plan

Manual Aspiration Thrombectomy

Device

Thrombus aspiration

Primary outcomes

  1. Occurrence of Cardiovascular death

    Time frame: up to 30 days

    time to event analysis

Secondary outcomes

  1. Occurrence of Cardiovascular death

    Time frame: up to 180 days

    time to event analysis

Other outcomes

  1. Occurrence of Stroke

    Time frame: up to 30 days

    time to event analysis

Sponsors and collaborators

Lead sponsor

Population Health Research Institute

Other

Collaborators

  • Region Örebro County
  • University Medical Center Groningen
  • University of Groningen
  • Uppsala University

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Sep 17, 2015
Registry last updated
Oct 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.