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NCT Number: NCT06879483

Thoraco-laparoscopic Partial Esophagogastrectomy for Management of Esophageal Cancer

Thoraco-laparoscopic partial esophagogastrectomy has emerged as a promising minimally invasive alternative, combining thoracoscopy and laparoscopy to reduce the trauma associated with open surgery.Early and intermediate-term outcomes provide critical information on both the oncological efficacy and functional benefits of the procedure. By examining recurrence rates within the first 12-24 months, this study will provide valuable insights into the oncological robustness of this approach compared to more invasive approaches.

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Key information

Conditions

Esophageal Cancer Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Neoplasms Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with resectable esophageal cancer (stages I-III).
  • Suitable for thoraco-laparoscopic partial esophagogastrectomy.
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

Exclusion criteria

  • Presence of distant metastasis at diagnosis.
  • History of previous esophageal or gastric surgery.
  • Contraindications to laparoscopy or thoracoscopy.

Treatment and study plan

Thoraco-laparoscopic partial esophagogastrectomy

Procedure
  • Laparoscopic Phase:
  • The stomach is mobilized, and a part of it is resected to include the lower esophageal segment.
  • Left gastric nodes, the splenic and common hepatic nodes are dissected.
  • A gastric tube is created using endoscopic staplers for esophageal reconstruction and fixed to the proximal gastrectomy specimen using sutures
  • Thoracoscopic Phase:
  • The patient is positioned in prone position
  • Three small incisions are made in the thorax
  • Further esophageal mobilization through a right thoracoscopy is performed in left lateral decubitus. Periesophageal nodes are retrieved en bloc. Left and right paratracheal and subcarinal lymph nodes are resected separately. The esophagus is transected at the tumor's proximal margin.
  • Reconstruction:
  • An anastomosis (esophagogastric connection) is performed to restore continuity, typically using a circular stapler or hand-sewn technique.

Primary outcomes

  1. Immediate Postoperative complications

    Time frame: first month post operative

    30-day morbidity and mortality (using Clavien-Dindo classification)

  2. Dysphagia

    Time frame: Collected at base line preoperative,one month, and 12 months post-surgery.

    yes or no

  3. resection margin status

    Time frame: 2 weeks postoperative

    resection margin status (R0/R1/R2)

  4. lymph node yield.

    Time frame: first month post operative

    number of lymph nodes in specimen

  5. regurgitation

    Time frame: Collected at one month, and 12 months post-surgery.

    yes or no

Secondary outcomes

  1. recurrence rate

    Time frame: first year post operative

  2. body mass index

    Time frame: Collected at base line preoperative,one month, and 12 months post-surgery.

  3. serum albumin

    Time frame: Collected at base line preoperative,one month, and 12 months post-surgery.

Study contacts

Contact information is provided by the study sponsor or research team.

ahmed m salah eldin, assistant lecturer of general

CONTACT

[email protected]

+201001329315

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Collaborators

  • Mansoura University

Registry information

Official study title

Early and Intermediate Term Outcomes of Thoraco-laparoscopic Partial Esophagogastrectomy for Management of Esophageal Cancer

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Mar 17, 2025
Registry last updated
Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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