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OpenTrials
Completed

NCT Number: NCT07143344

This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.

A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.

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Key information

Conditions

Bleeding on Probing Plaque Control Pocket Depth Saliva Microbiome

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Helsinki

Tampere, 33100, Finland

About this study

Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients or patients with systemic diseases with good cognitive abilities
  • with or without xerostomia.

Exclusion criteria

  • use of other mouthwash products, including chlorhexidine
  • current use of antibiotics.

Treatment and study plan

Fermented lingonberry juice sprey

Other

Patented fermented lingonberry juice sprey

Other names: FLJ, fermented lingonberry juice

Primary outcomes

  1. The effects of fermented lingonberry spray in the mouth.

    Time frame: Up to one month

    Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month.

  2. the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis.

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Lahanna oy

Other

Collaborators

  • University of Helsinki

Registry information

Official study title

The Effect of Fermented Lingonberry Spray on Oral Health - The Pilot Study

Acronym: FLJS_TRE

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 27, 2025
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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