This Present Study Can be Used by Clinicians Who Treat Psychiatric Patients: Dentists Might Expect Xerogenic Side Effects of Specific Psychiatric Drugs Which Can Affect Dental Treatment, and the Results Can Help Psychiatrist to Choose the Less Xerogenic Psychiatric Medication

The goal of this observational study is to learn about the effects of psychiatric drug therapies on intra- and extra-oral sicca symptoms and salivation. The main question that it aims to answer is:

Does taking psychiatric medication cause oral dryness and/or any changes on whole and minor saliva secretion? Participants taking psychiatric medication answered a 16-question questionnare, and their saliva production was measured by Periotron device and by spitting method.

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Key information

Conditions

Psychiatric Disorders Mental Disorders Xerostomia Due to Hyposecretion of Salivary Gland

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

In the psychiatric group, the inclusion criteria was taking specific psychiatric medications.

Exclusion criteria

In the control group the exclusion criteria was reporting any diseases and taking medicines.

Treatment and study plan

Primary outcomes

Unstimulated whole saliva flow rate (UWS)

Time frame: through study completion, an average of 1 year

UWS was determined using the "spitting" method (Sreebny 2000). Whole saliva was collected for 5 minutes into a previously weighted empty cup, and then measured again after collecting the saliva. The results are in ml/min.
Minor salivary gland (MSG) secretions

Time frame: Through study completion, an average of 1 year

Palatal and labial MSG flow rates were measured by the Periotron 8010® (Oraflow Inc. Amytiville, USA) device with filter paper discs. The results are transferred into µl/cm2/min.

Sponsors and collaborators

Lead sponsor

Semmelweis University

Other

Registry information

Official study title

Xerogenic Potential of the Most Frequently Prescribed Psychiatric Drugs

Important dates

Study start: 2013
Primary completion: 2018
Study completion: 2018
First posted: Apr 9, 2025
Registry last updated: May 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed