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OpenTrials
Completed

NCT Number: NCT04155697

Thirdhand Smoke Contamination in a Neonatal Intensive Care Unit (NICU)

The purpose of the study is to quantify the efficacy of hand washing (HW) and ethyl alcohol-based hand sanitizer (S) for third-hand smoke (THS) removal in a sub-sample of non-staff smokers using nicotine wipes on adjacent fingers before and after HW/S.

The hypotheses are that detectable levels of surface nicotine will remain on participants' fingers, regardless of hand washing (HW) and ethyl alcohol-based hand sanitizer (S) attempts and that greater finger levels of surface nicotine will remain after alcohol sanitization compared to hand washing.

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Key information

Conditions

Nicotine Exposure

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

():

  • Any non-staff participants visiting the NICU (including friends and family members of the infants' caregivers)
  • Consented to and provided a finger wipe
  • Report being a smoker
  • Smoking status verified by an exhaled carbon monoxide (CO) level of >7 parts per million

Exclusion criteria

  • Unwilling to comply with research procedures (i.e., finger wipes)
  • Does not speak English.

Treatment and study plan

2% Chlorohexidine Gluconate soap

Drug

Participants will wash hands for 30 seconds with 2% Chlorohexidine Gluconate soap.

62% ethyl alcohol-based hand sanitizer

Drug

Participants will apply 62% ethyl alcohol-based hand sanitizer for 30 seconds

Primary outcomes

  1. Nicotine level on finger #1

    Time frame: baseline

    Nicotine will be sampled from one finger of each participant's dominant hand (thumb, index, or middle finger). Finger will be wiped and nicotine level will be quantified.

  2. Nicotine level on finger #2

    Time frame: 5 minutes after hand washing or sanitizing

    Nicotine will be sampled from one finger of each participant's dominant hand (thumb, index, or middle finger). Finger will be wiped and nicotine level will be quantified.

  3. Nicotine level on finger #3

    Time frame: 1 hour after hand washing or sanitizing

    Nicotine will be sampled from one finger of each participant's dominant hand (thumb, index, or middle finger). Finger will be wiped and nicotine level will be quantified.

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Nov 7, 2019
Registry last updated
May 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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