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Completed

NCT Number: NCT04470635

Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children

The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.

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Key information

Conditions

Periodontal Diseases Autoimmune Diseases Diabetes Mellitus Diabetes Mellitus, Type 1 Endocrine System Diseases Glucose Metabolism Disorders Immune System Diseases Metabolic Diseases Mouth Diseases Nutritional and Metabolic Diseases Stomatognathic Diseases

Age range

7 year–14 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sultan Keles

Aydin, Turkey (Türkiye)

About this study

Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children diagnosed as type 1 diabetes mellitus
  • Age between 7-14 years

Exclusion criteria

  • Having another systemic problem except type 1 diabetes mellitus
  • Children carrying orthodontic appliances

Treatment and study plan

ELISA

Diagnostic Test

Saliva sample collection

Other names: Thiol/disulphide measurement, Total thiol, native thiol and disulphide level

Primary outcomes

  1. Vascular endothelial growth factor level

    Time frame: Baseline

    Vascular endothelial growth factor level in saliva

Secondary outcomes

  1. Thiol/disulphide measurement

    Time frame: Baseline

    Total thiol, native thiol and disulphite level in saliva

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Official study title

Thiol/Disulphide Homeostasis and Salivary Vascular Endothelial Growth Factor Levels in Type 1 Diabetic Patients With Gingivitis

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jul 14, 2020
Registry last updated
Jan 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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