Thereapeutic Recommendantion for Children With a Hodgkin Lymphoma

In high-income countries, therapeutic outcomes exceed 90% and therapeutic de-escalation is necessary to reduce mainly the effects of long-term radiotherapy. Within the same country, there are also differences between the therapeutic protocols used in the different centres.

The Experience of Sub-Saharan African Units of the Franco-African Paediatric Oncology Group (GFAOP) in the treatment of pediatric Hodgkin lymphoma in 104 patients was based on chemotherapy alone. The latter was based on COPP/ABV cures without complementary irradiation adapted to the initial stratification and modulated according to the morphological response. Overall survival at 5 years was 82% at 30 months after a median decrease of 17 months.

It seemed appropriate to bring together in a single committee the representatives of the various pilot units in order to standardize the therapeutic protocols in the African countries.

So with this recommendation the GFAOP propose a simple and reproducible staging according to clinical, biological and radiological data.

• Develop standardized but different therapeutic recommendations based on the availability or lack of radiation therapy in the pilot unit.

Inclusion criteria

under 18 years of age at diagnosis

• suffering from "classical" Hodgkin's disease according to the WHO classification.
• with no history of hematological malignancies or constitutional or acquired immune deficiencies

Exclusion criteria

• Over 18 years of age at diagnosis
• A history of hematological malignancies or a history of constitutional or a history of acquired immune deficiencies