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OpenTrials
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NCT Number: NCT07225192

Therapy and Tech Study

The investigators want to test if gen AI can support therapy by recruiting patients already in therapy.

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Key information

Conditions

Generalized Anxiety Disorder (GAD) Anxiety Disorders Depressive Disorder Depressive Disorder, Major Generalized Anxiety Disorder Major Depressive Disorder Mental Disorders Mood Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Recent advancements in AI have led to chatbots, such as ChatGPT, capable of providing therapeutic responses. Early research evaluating chatbots' ability to provide relationship advice and single-session relationship interventions has showed that both laypeople and relationship therapists rate them high on attributes such as empathy and helpfulness. The investigators want to test if chatbots can be a good adjunct to traditional therapy. The investigators hypothesize that participants who regularly use a chatbot as an adjunct to traditional therapy will have better mental health outcomes. Participants will complete baseline, 4-week (post-intervention) and 4-week post-intervention measures and will be invited to gain their therapists ratings.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18+
  • US Resident
  • English-speaking
  • Self-report having been treated for or diagnosed with generalized anxiety disorder or major depressive disorder by a licensed provider (e.g., MD, DO, LPCC, LCSW, LMFT) in the past 12 months
  • Self-report currently being in individual therapy

Exclusion criteria

  • Ever diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, or hospitalized for suicidality

Treatment and study plan

Chatbot Therapy

Behavioral

This group will be asked to use an AI chatbot like chatgpt as an adjunct to their regular therapy

Primary outcomes

  1. Generalized Anxiety Disorder (GAD-7)

    Time frame: Baseline, 4-week follow-up, 8-week follow-up

    Questions about symptoms of generalized anxiety disorder. Scale is 0-21. Higher scores is a worse outcome.

  2. Patient Health Questionnaire (PHQ-9)

    Time frame: Baseline, 4-week follow-up, 8-week follow-up

    Questions about symptoms of depression. Scale is 0-27. Higher score is a worse outcome.

Sponsors and collaborators

Lead sponsor

University of California, Irvine

Other

Collaborators

  • National Center for Complementary and Integrative Health (NCCIH)

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 6, 2025
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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