Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07371130

Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation

After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.

This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

About this study

After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane.

In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.

In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults in good general health
  • Indication for tooth extraction in sites planned for delayed implant placement
  • Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability
  • Extraction sockets presenting absence of the buccal (vestibular) bone wall
  • Signed informed consent

Exclusion criteria

  • Systemic conditions affecting bone healing
  • Uncontrolled periodontal disease
  • Smoking >10 cigarettes/day
  • Pregnancy or lactation
  • Use of medications interfering with bone metabolism

Treatment and study plan

Socket preservation

Procedure

After atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.

Primary outcomes

  1. VAS

    Time frame: 1 day , 3 days , 7 days ,14 days

    Postoperative pain assessment using the Visual Analog Scale (VAS) (1-10)

  2. Analgesic consumption

    Time frame: 7 days

    recorded as the number of ibuprofen 400 mg tablets taken

Secondary outcomes

  1. Histological Evaluation

    Time frame: 4- 6 month

    • Prior to implant placement, a CBCT scan will be performed to assess alveolar bone volume and morphology.
    • During implant site preparation, a bone core biopsy will be harvested using a trephine bur.
    • The bone sample will undergo histological and histomorphometric analysis to evaluate:
    • New bone formation
    • Residual graft material
    • Connective tissue percentage

Study contacts

Contact information is provided by the study sponsor or research team.

Domenico Patarino, Dr.

CONTACT

[email protected]

+393394359824

Giuseppe D'Albis, Dr.

CONTACT

[email protected]

+393495103642

Sponsors and collaborators

Lead sponsor

University of Bari Aldo Moro

Other

Registry information

Official study title

Evaluation of Low-Intensity Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation: A Clinical Trial

Acronym: APnanotecnolog

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 27, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.