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Completed

NCT Number: NCT04485975

Therapeutic Plasma Exchange in Thyrotoxicosis

Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

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Key information

Conditions

Thyrotoxicosis Endocrine System Diseases Hyperthyroidism Thyroid Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • thyrotoxicosis unresponsive to medication
  • adverse reaction to the medications
  • need for rapid treatment in patients that need urgent surgery

Exclusion criteria

  • The patients who did not undergo surgery post-therapeutic plasma exchange
  • Preoperative hypocalcemia,
  • hemodynamically unstable patients
  • patients not suitable for central catheter placement

Treatment and study plan

Therapeutic plasma exchange

Device

Therapeutic plasma exchange filtrates plasma and decreases thyroid hormone concentration in the blood

Other names: Thyroidectomy

Primary outcomes

  1. Thyroid hormone levels of patients after therapeutic plasma exchange

    Time frame: 1 week before the operation

    Concentration of serum thyroid hormone levels before thyroidectomy

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Official study title

Preoperative Therapeutic Plasma Exchange and Surgical Treatment in Thyrotoxicosis Patients: a Single-centre Retrospective Cohort Study

Important dates

Study start
1999
Primary completion
2019
Study completion
2020
First posted
Jul 24, 2020
Registry last updated
Jul 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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