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NCT Number: NCT07128875

Therapeutic Exercises for Pain and Disability in Knee Osteoarthritis

This study aims to evaluate the effectiveness of structured therapeutic exercises in reducing pain and disability among older adults diagnosed with knee osteoarthritis. The intervention will involve a supervised physical therapy program targeting muscle strength, joint mobility, and functional capacity. Participants will undergo 6 weeks of therapy, and improvements in pain and physical function will be measured using validated scales.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

35 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Riphah international University Malakand Campus

Malakand, Kpk, 23060, Pakistan

About this study

Knee osteoarthritis (OA) is a leading cause of chronic pain and mobility limitations in the elderly population. Therapeutic exercises play a significant role in managing OA symptoms by strengthening the quadriceps, improving joint flexibility, and reducing stiffness. This study will enroll 60 participants aged 50-75 years diagnosed with knee OA. They will undergo a combination of strengthening, range of motion (ROM), and stretching exercises tailored to their condition. The intervention also includes adjunctive modalities such as hot pack and TENS to reduce pain and facilitate muscle engagement. Outcome measures will assess pain intensity, functional ability, and lower limb endurance before and after the intervention.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Minimum Age: 50 Years Maximum Age: 75 Years Sex: All Accepts Healthy Volunteers: No

Inclusion criteria

  • Diagnosed with knee OA
  • Aged 50-75 years
  • Experiencing pain or functional limitation
  • Able to attend supervised sessions
  • Provided informed consent

Exclusion criteria

- History of total knee replacement

  • Severe cardiovascular or neurological conditions
  • Acute injury or fracture in lower limb
  • Uncontrolled hypertension or diabetes

Treatment and study plan

Exercise + TENS + Hot Pack

Other

Therapeutic Exercises with Hot Pack and TENS This intervention focuses on improving physical function and reducing pain through structured therapeutic exercises for knee OA patients. The program includes Warm-Up (10 min): Light walking or stationary cycling. 2. Range of Motion (ROM) Exercises: Heel slides, seated knee flexion/extension. 3. Strengthening Exercises:

Quadriceps sets Straight leg raises Mini squats (pain-free range)

Seated knee extensions with resistance band 4. Stretching Exercises:

Hamstring stretch Calf stretch Quadriceps stretch 5. Cool Down (5-10 min): Breathing and relaxation. 6. Hot Pack (15 min) + TENS (10 min): Applied pre and post exercises for pain relief and muscle relaxation.

Exercise

Other

Warm-Up (10 min): Light walking or stationary cycling. 2. Range of Motion (ROM) Exercises: Heel slides, seated knee flexion/extension. 3. Strengthening Exercises:

Quadriceps sets Straight leg raises Mini squats (pain-free range)

Seated knee extensions with resistance band 4. Stretching Exercises:

Hamstring stretch Calf stretch Quadriceps stretch 5.

Primary outcomes

  1. Pain Intensity

    Time frame: 6 Months

    Pain intensity will be assessed using the Visual Analog Scale (VAS), which ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores represent worse outcomes.

Secondary outcomes

  1. Change in Physical Disability

    Time frame: 6months

    Physical disability will be measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The WOMAC consists of 24 items scored from 0 (none) to 4 (extreme), yielding a total score range from 0 to 96, where higher scores indicate worse disability

Study contacts

Contact information is provided by the study sponsor or research team.

Dr.Nadeem Ahmad, MS

CONTACT

[email protected]

03451915105

Dr.Nadeem Ahmad, MS

CONTACT

[email protected]

03028367237

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effectiveness of Therapeutic Exercises in Reducing Pain and Disability in Knee Osteoarthritis Patients in Older Adults

Acronym: OA

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 19, 2025
Registry last updated
Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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