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Completed

NCT Number: NCT07033312

Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional supplement based on hyaluronic acid with hyaluronic acid intra-articular Injection on symptomatic knee osteoarthritis. Researchers will compare it to those who receive only hyaluronic acid injection to see if the combined treatment is better.

Participants will receive a total of three months of oral hyaluronate or placebo agents.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

60 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Taichung Veterans General Hospital

Taichung, Taiwan, 40705

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Radiological evidence of osteoarthritis Ahlbäck stage I-III.
  • Had knee effusion at the suprapatellar recess under ultrasonographic examination.
  • Age between 60 and 75 years old.

Exclusion criteria

  • Rheumatological disorders
  • Accidental trauma or fractures involving knees in the past three months
  • Neuropathic pain involving lower limbs
  • Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders.
  • Depression and cognitive problems
  • Pregnancy

Treatment and study plan

oral hyaluronate and injection

Drug

The patient receives oral hyaluronate and hyaluronate injection

hyaluronate injection

Drug

The patient receives hyaluronate injection only

Primary outcomes

  1. The Western Ontario and McMaster Universities Arthritis Index (WOMAC)

    Time frame: From enrollment to the end of treatment at 12 weeks

    The Western Ontario and McMaster Universities Arthritis Index (WOMAC) aim to reveal pain, stiffness and function of the knee, the minimum and maximum values are 0 and 68, and a higher score mean a worse outcome.

Secondary outcomes

  1. knee strength

    Time frame: From enrollment to the end of treatment at 12 weeks

    knee extension and flexion torque detected by isokinetic machine

  2. Timed up and go test

    Time frame: From enrollment to the end of treatment at 12 weeks

    the time needed for a patient sits on a chair, stands up walks for 3 meters, and then go back down

Sponsors and collaborators

Lead sponsor

Taichung Veterans General Hospital

Other

Registry information

Official study title

Therapeutic Effect of Combined Treatment of Oral Nutritional Supplement Based on Hyaluronic Acid With Hyaluronic Acid Intra-articular Injection on Symptomatic Knee Osteoarthritis

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jun 24, 2025
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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