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OpenTrials
Completed

NCT Number: NCT02928939

Therapeutic Conflicts and Multimorbidity

Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.

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Key information

Conditions

Gastrointestinal Hemorrhage Chronic Disease Diabetes Complications Diabetes Mellitus Digestive System Diseases Disease Attributes Endocrine System Diseases Gastrointestinal Diseases Hemorrhage Multimorbidity Multiple Chronic Conditions Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich

Zurich, Switzerland

About this study

The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inpatients at the University Hospital Zurich, USZ
  • Male and female patients, aged 18 years or older
  • Fulfilling the criteria for Use Case A or B (i.e. patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs, Use Case A or patients with diabetes mellitus and/or systemic corticosteroids, Use Case B)

Exclusion criteria

  • If potential participants have a statement in the electronic medical record or elsewhere to refuse study participation, this represents exclusion criteria.

Treatment and study plan

drug-drug or drug-disease interaction

Other

Primary outcomes

  1. Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs

    Time frame: 5 years

    Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding?

  2. Patients with diabetes mellitus and systemic corticosteroids

    Time frame: 5 years

    Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus?

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • Center of Competence Multimorbidity, Zurich
  • University Hospital, Zürich

Registry information

Official study title

Therapeutic Conflicts in Hospitalized Patients: Retrospective Analyses of Patients With GI Bleeding or Exacerbated Diabetes and Impact of Multimorbidity.

Important dates

Study start
2016
Primary completion
2020
Study completion
2021
First posted
Oct 10, 2016
Registry last updated
Apr 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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