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NCT Number: NCT05545176

The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries

Objectives/Hypotheses

1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate. 2. Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation / ventricular tachycardia; VF/VT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules. 3. We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules. 4. We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University

Taipei, Taiwan

Location status: Recruiting

Location contact

Shu-Hsien Hsu, MPH

CONTACT

[email protected]

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • out of hospital cardiac arrest (OHCA) patients

Exclusion criteria

  • age <18 years
  • non-EMS transport to the emergency department
  • obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders
  • missing data despite meeting the inclusion criteria.

Treatment and study plan

termination of resuscitation rules

Other

Use retrospective data to analyze the accuracy termination of resuscitation rules and further develope a termination of resuscitation rule.

Primary outcomes

  1. survival to hospital discharge

    Time frame: survival to 30-day hospitalisation

    survival to 30-day hospitalisation

Secondary outcomes

  1. Cerebral Performance Categories Scale (CPC)

    Time frame: CPC within 30-day hospitalisation

    CPC Scale 1~5, minimum value: 1; maximum value:5; lower score means greater outcome

Study contacts

Contact information is provided by the study sponsor or research team.

Shu-Hsien Hsu, MPH

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Collaborators

  • Singapore Clinical Research Institute

Registry information

Official study title

The Validation and Development of Termination-of-Resuscitation (TOR) Rules in Patients Following Out-of-Hospital Cardiac Arrest (OHCA) in Asia Countries

Important dates

Study start
2007
Primary completion
2032
Study completion
2032
First posted
Sep 19, 2022
Registry last updated
Feb 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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