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Completed

NCT Number: NCT03376581

The Utility of Platelet Rich Plasma in Hair Loss

Platelet rich plasma (PRP) is an autologous preparation of human plasma with high concentration of platelets. Platelets release numerous growth factors, which stimulate cell proliferation and differentiation.

The purpose of this research is to investigate the potential of PRP injection for treatment of hair loss. Clinical outcomes will be assessed by noninvasive techniques including dermoscopy, multiphoton microscopy, optical coherence tomography, optical Doppler tomography and multispectral imaging.

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Key information

Conditions

Androgenetic Alopecia Alopecia Hair Diseases Hypotrichosis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall

Irvine, California, 92697, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 18 years of age
  • Ability to understand and carry out instructions
  • Diagnosed with alopecia

Exclusion criteria

  • Inability to understand and.or carry out instructions
  • Pregnant women
  • Use of any topical medication (such as minoxidil or any other solution for hair growth), oral medication (finasteride, dutasteride, or antiandrogens), laser therapy, or chemotherapy, within the preceding 4 weeks.
  • Personal medical history of bleeding disorders
  • Personal medical history of platelet dysfunction syndrome
  • Anti-coagulation therapy or nonsteroidal anti-inflammatory drugs in the last 1 week.

Treatment and study plan

Platelet rich plasma

Procedure

Blood drawn from each participant will be spun down to separate platelets. Platelets will be injected into that patient's scalp.

Primary outcomes

  1. Hair density to measure the efficacy of treatment

    Time frame: 6 months

Secondary outcomes

  1. Hair count (number of hairs/0.65 cm2)

    Time frame: 6 months

  2. Terminal hair density

    Time frame: 6 months

  3. Anagen hair percentage

    Time frame: 6 months

  4. Telogen hair percentage

    Time frame: 6 months

  5. Anagen/telogen ratio

    Time frame: After 3 and 6 months

  6. Changes in hair structure, diameter, and blood flow

    Time frame: 6 months

    As measured by optical coherence tomography

Sponsors and collaborators

Lead sponsor

University of California, Irvine

Other

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Dec 18, 2017
Registry last updated
Feb 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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