The Utility of Ischemia Modified Albumin (IMA) in Sepsis

Sepsis is an unconquered challenge in medicine, affecting people of all ages and demographics. Severe sepsis affects approximately 751,000 patients in the United States per annum, with healthcare costs approaching $16.7 billion dollars a year. Mortality from severe sepsis and septic shock approaches 30 - 70 % with 215,000 deaths annually. Thus, sepsis is a disease with healthcare dollars and mortality rates approaching those of heart disease and cancer.

Identifying patients with sepsis, and in particular hypoperfusion, is a challenge to the clinician. A variety of clinical and laboratory findings are helpful, but there is no single test to identify sepsis or assess its severity.

Ischemia and reactive oxygen species play a significant role in the pathogenesis of sepsis. Moreover, there is evidence to suggest that septic shock results in dysfunction of autoregulatory mechanisms and misdistribution of blood flow, precipitating both regional and global ischemia. A method that can help rapidly assess hypoperfusion would be clinically useful. Ischemia modified albumin (IMA) is a potential marker for ischemia in acute coronary syndrome patients; thus, it is hypothesized that IMA may be also useful as a prognostic biomarker for clinical identification of infection and the severity of illness in patients with sepsis.

Inclusion criteria

for Sepsis Subjects:

• 18 years of age or older
• Able to provide informed consent
• Clinical suspicion of infection

Exclusion criteria

for Sepsis Subjects:

• Active chest pain of suspected cardiac origin
• ST elevation myocardial infarction or dynamic ST changes on EKG
• Pregnant women
• Cocaine use
• Liver disease
• Unable to speak or understand the English language

Inclusion criteria

for Control Subjects:

• 18 years of age or older
• Emergency Department presentation as a result of a non-infectious etiology as determined by the treating clinicians
• Able to provide informed consent

Exclusion criteria

for Control Subjects:

• Suspected Infection
• Temperature >100.4°F
• Pregnant women
• Possible cardiac, intestinal or cerebral ischemia
• Liver disease
• Any source of inflammation as part of their presentation
• cancer, any type