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NCT Number: NCT07450248

The Use of Telephone-based ACT for Quitting Alcohol in the Young Population With Hazardous or Harmful Alcohol Use.

Objectives: To investigate the effectiveness of a telephone-based acceptance and commitment therapy (ACT) in assisting young adult drinkers with hazardous or harmful alcohol use (HH drinkers) to quit drinking.

Hypothesis to be tested:

Primary hypothesis: 1) those who receive telephone-based ACT will report a significantly higher biochemical validated abstinence than the control groups.

Secondary hypotheses are that compared with the control groups, those who receive telephone-based ACT will show: 2) significantly higher self-reported 30-day abstinence, 3) significantly greater reduction in drinking, and 4) significantly higher psychological flexibility.

Design and subjects: A Hong Kong randomized controlled trial with 2-arm waitlist controlled trial design on 288 individuals (aged 18-35 years, able to read Chinese and speak Cantonese, and with AUDIT scores≥8).

Study instruments: Biochemical-validated abstinence (Urine strips), timeline Follow-Back questionnaire, self-reported 30-day abstinence and Personalized Psychological Flexibility Index, Short-Form 6 Dimensions and semi-structured interviews.

Interventions:

The intervention group(n=144) will receive 6-weekly telephone-based ACT. The waitlist control group (n=144) will receive 6-weekly telephone-based social support intervention.

Main outcome measures: Primary outcome is biochemical-validated abstinence at the 6-month follow-up. Secondary outcomes include self-reported 30-day abstinence alcohol reduction, and psychological flexibility at baseline, post-program, 1-, 3-, and 6-month follow-ups.

Data analysis: Descriptive statistics, generalized estimating equations, multiple imputation, intention-to-treat, per protocol analyses, and cost-effectiveness analysis.

Expected results: The telephone-based ACT is effective in assisting HH drinkers to quit drinking.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • (1)aged 18-35 years,37-38
  • (2)able to read Chinese and speak Cantonese
  • (3)have AUDIT scores≥8.

Exclusion criteria

  • (1) those who have a serious mental illness (Kessler Psychological Distress Scale7 with a score of ≥13)

Treatment and study plan

Telephone-based ACT

Behavioral

Each participant will join a six-session weekly telephone-based ACT programme conducted by the interventionists. Each session will last approximately 45-60 minutes.

Telephone-based social support

Behavioral

Participants will receive weekly 45-minute telephone-based social support from an interventionist(not involved in the intervention group) for 6 weeks, which mimics the time and attention received by those in the intervention group.

Primary outcomes

  1. biochemically-validated abstinence

    Time frame: at the 6-month follow-up

    The urine strips will be used for testing the content of ethyl glucuronide(a by-product of alcohol). Participants who self-report quitting drinking within the past 30 days at the 6-month follow-up will be invited to do the test.

Secondary outcomes

  1. self-reported 30-day alcohol abstinence

    Time frame: at post-programme(T1) and at the 1-month(T2), 3-month(T3) and 6-month(T4) follow-ups

  2. self-reported 30-day reduction in alcohol consumption

    Time frame: at post-programme(T1) and at the 1-month(T2), 3-month(T3) and 6-month(T4) follow-ups

    reduction in alcohol consumption refer to: 50% or more reduction in average alcohol consumption per day when compared with baseline at T0

  3. psychological flexibility

    Time frame: at post-programme(T1) and at the 1-month(T2), 3-month(T3) and 6-month(T4) follow-ups

    Personalised Psychological Flexibility Index(PPFI) will be used to measure psychological flexibility by 19 items rating on a 7-point scale. Higher scores represent greater psychological flexibility. It has been validated among Chinese college students.

Study contacts

Contact information is provided by the study sponsor or research team.

Ka Wai Katherine LAM, Doctor of Philosophy

CONTACT

[email protected]

+852 27666420

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Registry information

Official study title

A Randomized Controlled Trial of Telephone-based Acceptance and Commitment Therapy to Assist Young Adults With Hazardous or Harmful Alcohol Use to Quit Drinking

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Mar 4, 2026
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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