Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06171204

The Use of Stromal Vascular Fraction for Knee Arthrosis

A trial to investigate the safety and efficacy of SVF for the treatment of knee arthrosis.

Patients will undergo a single liposuction to obtain the SVF. The SVF will then be isolated and frozen in our laboratory. The SVF will then be injected up to 2 times into the fat pad of the patient's knee.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Knee Arthrosis

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UZ GENT

Ghent, Oost-Vlaanderen, 9000, Belgium

Location status: Recruiting

About this study

Stromal Vascular Fraction (SVF) from adipose tissue is increasingly being used in the clinic for a variety of conditions (skin disorders, joint pain, etc.). SVF is a collective term for cells that can be obtained from liposuction fat. These cells can be separated from the fat by mechanical processing of the liposuction fat combined with an additional centrifugation.

Despite the fact that enough SVF can be isolated after such a liposuction for multiple treatments (>3), our research group has found a way to safely freeze SVF without significant loss of SVF cells. In this way, a patient would only have to undergo one liposuction and associated anesthesia to be able to obtain multiple SVF treatments.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Legal capacity
  • Osteochondral lesions
  • Inflammatory complaints
  • (Peri)tendinitis or tendinopathies and ligamentous injuries
  • Impingement complaints
  • Arthrofibrosis
  • Anterior knee pain

Treatment and study plan

Injection of SVF in fat pad of the knee

Procedure

Knee fat pad injection with SVF at orthopaedics/physical medicine outpatient clinic

Primary outcomes

  1. Evaluation of the safety of SVF injections after cryo preservation

    Time frame: 1 year

    The patient will complete the KOOS questionnaire (Knee Injury and Osteoarthritis Outcome Score) on several timepoints.

Study contacts

Contact information is provided by the study sponsor or research team.

Bernard Depypere, MD

CONTACT

[email protected]

093325730

Jessie De Kinder

CONTACT

[email protected]

093321373

Sponsors and collaborators

Lead sponsor

University Hospital, Ghent

Other

Registry information

Official study title

Gebruik Van Stromale Vasculaire Fractie Uit Vetweefsel Na Invriezing Voor Knie Arthrose

Important dates

Study start
2022
Primary completion
2025
Study completion
2026
First posted
Dec 14, 2023
Registry last updated
Nov 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.