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OpenTrials
Completed

NCT Number: NCT00772564

The Use of Statins for Myocardial Death Prevention

The administration of high dose HMG-CoA reductase inhibitors (Statins) to patients with acute ST-elevation MI (hypoxia/ischemia) who are treated with primary PCI (reoxygenation/ reperfusion) will protect their cardiomyocytes from death and thus preserve LV ejection fraction.

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Key information

Conditions

Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

30 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Rambam Health Care Campus

Haifa, Haifa District, 31096, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients suffering from acute ST elevation resulting from myocardial infarction, Killip Classification 1 and 2 will be included at-random to either group. Included subjects should be able to give their informed consent to participate in this study.

Exclusion criteria

  • The impossibility to give the required informed consent.
  • Known allergy to Atorvastatin.
  • Base line serum creatinine of 1.4 mg/dL.
  • Killip Classification 3 and 4.
  • Persisting vomiting.
  • History of previous liver disease.
  • History of previous muscle disease or rabdomyolisis.
  • Treated already with high dose atorvastatin
  • Non Compliance.

Treatment and study plan

atorvastatin

Drug

Oral Atorvastatin

Primary outcomes

  1. Heart EcoCardiography and specific laboratory tests

    Time frame: Base line, second day and 60 days after myocardial infarction

Sponsors and collaborators

Lead sponsor

Rambam Health Care Campus

Other

Collaborators

  • Pfizer

Registry information

Official study title

The Use of Statins for Myocardial Death Prevention: From Cell to Bedside

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Oct 15, 2008
Registry last updated
May 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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