Recruiting

NCT Number: NCT07275190

The Use of Machine Learning Techniques for the Differential Diagnosis Between Eosinophilic Granulomatosis With Polyangiitis and Hypereosinophilic Syndrome

The purpose of this study is to collect clinical, laboratory, and instrumental data from patients with eosinophilic granulomatosis with polyangiitis or hypereosinophilic syndrome, which will then be analyzed using artificial intelligence techniques with the aim of identifying characteristics that differentiate the two diseases and can predict the response to the treatment plan.

Recruiting

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Key information

Conditions

EGPA - Eosinophilic Granulomatosis With Polyangiitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmune Diseases Cardiovascular Diseases Churg-Strauss Syndrome Eosinophilia Granuloma HES - Hypereosinophilic Syndrome Hematologic Diseases Hemic and Lymphatic Diseases Hypereosinophilic Syndrome Immune System Diseases Leukocyte Disorders Lymphatic Diseases Lymphoproliferative Disorders Skin Diseases Skin Diseases, Vascular Skin and Connective Tissue Diseases Systemic Vasculitis Vascular Diseases Vasculitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fondazione IRCCS Policlinico San Matteo, SC Reumatologia

Pavia, 27100, Italy

Location status: Recruiting

Location contact

Carlomaurizio Montecucco

CONTACT

[email protected]

390382502948

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18 years of age or over
A diagnosis of EGPA or HES
Willing and able to give informed written consent, or willing to give permission for a nominated friend or relative to provide written informed assent if they are unable to do so because of physical disabilities

Exclusion criteria

Lack of a confirmed diagnosis of EGPA or HES.
Other causes of eosinophilia

Treatment and study plan

Blood draw for the laboratory assessment

Procedure

Blood draw for the laboratory assessment

Primary outcomes

characteristics that are different between HES and EGPA

Time frame: 18months

Study contacts

Contact information is provided by the study sponsor or research team.

Alessandra Milanesi

CONTACT

[email protected]

0382502498

Carlomaurizio Montecucco

CONTACT

[email protected]

390382502948

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 10, 2025
Registry last updated: Dec 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting