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NCT Number: NCT02326324

The UHSM Cardiovascular Magnetic Resonance Study

This study aims to investigate the diagnostic and prognostic utility of cardiovascular magnetic resonance (CMR) imaging in a large cohort of unselected patients who are undergoing CMR scanning for clinical indications (i.e. suspected/confirmed cardiovascular disease). CMR indices will be related to the presence and severity of cardiovascular disease and other markers of cardiovascular and health status.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Cardiovascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of South Manchester

Manchester, Greater Manchester, M23 9LT, United Kingdom

About this study

Patients will undergo CMR scanning in the usual clinical manner. As part of the study, patients will undergo approximately 5 minutes of extra CMR scanning. Cardiovascular anatomical, structural and functional data will be recorded, including data pertaining to myocardial characteristics (e.g. extracellular volume, oedema, fibrosis, infarction, function, perfusion), pericardial disease; valvular disease; vascular structure and function.

Blood sampling will be performed on the same day as CMR scanning for assessment of serum/plasma markers of cardiovascular disease and health status, and DNA analysis. Health questionnaires will be completed on the day of CMR scanning.

Follow-up information regarding health status, demographics and concurrent medical conditions and treatments will be obtained over a 10 year period following CMR scanning.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any adult patient undergoing clinically indicated CMR scanning at the UHSM CMR Unit.

Exclusion criteria

Age < 18 years, imprisonment, inability to provide informed consent.

Treatment and study plan

Primary outcomes

  1. All cause mortality

    Time frame: 10 years with planned interim analyses

Secondary outcomes

  1. Cardiovascular death

    Time frame: 10 years with planned interim analyses

  2. Hospitalisation for heart failure

    Time frame: 10 years with planned interim analyses

  3. Development of cardiovascular disease

    Time frame: 10 years with planned interim analyses

  4. Development of complications of cardiovascular disease

    Time frame: 10 years with planned interim analyses

Sponsors and collaborators

Lead sponsor

Manchester University NHS Foundation Trust

Other Gov

Collaborators

  • University of Pittsburgh Medical Center

Registry information

Official study title

The University Hospital of South Manchester Cardiovascular Magnetic Resonance Study

Acronym: UHSM CMR

Important dates

Study start
2015
Primary completion
2029
Study completion
2029
First posted
Dec 29, 2014
Registry last updated
Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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