Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06876701

The Treatment of Newly Diagnosed CD19+Mixed Phenotype Acute Leukemia in Adults

Evaluation the efficacy and safety of the combination of injectable bevacizumab, low-intensity chemotherapy, and venula in the treatment of newly diagnosed CD19+mixed phenotype acute leukemia in adults

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Shanghai Zhaxin integrated hospital of traditional Chinese and Western Medicine

Shanghai, China

Location contact

Wang Chun

CONTACT

[email protected]

13386259777

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients fully understand this study, voluntarily participate and sign an informed consent form (ICF);
  • Age: 18-75 years old (including boundary values of 18 and 75);
  • Clinically diagnosed adult Mixed Phenotype Acute Leukemia (WHO 2016 criteria) patients with CD19 positivity

Exclusion criteria

The subject's previous history of anti-tumor treatment meets one of the following conditions:

  • Individuals who have previously received bevacizumab
  • Individuals who have received CAR-T therapy or other gene modified cell therapies prior to screening;
  • Within 5 half lives of the first use of the investigational drug, having received anti-tumor treatment including surgery, chemotherapy, targeted therapy, or participating in other clinical trials and receiving clinical trial medication;

Treatment and study plan

Bevacizumab

Drug

Evaluation of the efficacy and safety of the combination of injectable bevacizumab, low-intensity chemotherapy, and venula in the treatment of newly diagnosed CD19+mixed phenotype acute leukemia in adults

Primary outcomes

  1. Negative conversion rate of evaluable residual lesions (MRD)

    Time frame: 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Wang Chun

CONTACT

[email protected]

13386259777

Sponsors and collaborators

Lead sponsor

Ruijin Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Mar 14, 2025
Registry last updated
Mar 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.