The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine

Inclusion criteria

• Diagnosed as HCC through imaging and laboratory tests, and capable of undergoing laparoscopic anatomical resection.
• Surgical scope (defined by randomization stratification):Stratum 1: Major hepatectomy, involving the resection of at least 3 Couinaud liver segments, including right hemihepatectomy and extended right hemihepatectomy, etc.Stratum 2: Minor hepatectomy, involving the resection of no more than 2 Couinaud liver segments. This includes right posterior sectorectomy, right anterior sectorectomy, left lateral sectionectomy, single segmentectomy, etc.
• During the operation, the Pringle method is used to block the first hepatic portal. Each block lasts ≤ 15 minutes, and the blocking procedure is performed 2 to 4 times.
• Age: 18 - 80 years old. Gender: Open to both male and female. Body Mass Index (BMI): 18.5 - 28 kg/m².
• Child-Pugh grade A or B, with a score of ≤ 7; ASA grades I to III.
• Preoperative ICG R15 < 10%, and the residual liver volume/standard liver volume > 40%.
• A single HCC (hepatocellular carcinoma), with a tumor diameter of less than 10 cm, without distant metastasis or invasion of the portal vein system.
• Preoperative ALT < 2x ULN (upper limit of normal).
• No history of portal vein embolization prior to enrollment. If TACE treatment was previously received, it must have been completed > 6 months ago; if systemic anti-tumor drug therapy was previously received, it must have been completed > 4 weeks ago.
• No liver-damaging treatment drugs were used within two weeks prior to enrollment.

Exclusion criteria

• Reserve liver vascular damage, including: reconstruction after severance, ligation, embolization, thrombosis, etc
• Combined with abnormal coagulation function (prothrombin time prolonged by more than 3 seconds)
• Combining obstructive jaundice, severe heart disease, severe kidney disease and other serious illnesses
• During the operation, microwave treatment or a combination of microwave treatment was adopted
• More than 4 times of blocking at the first hepatic hilum, or a single blocking duration longer than 15 minutes
• Non-anatomic liver resection, where the remaining liver contains large areas of ischemic/edematous regions
• More than 1000ml of blood transfusion during the operation
• During the operation, an extra-hepatic disease was discovered. Other organs except the gallbladder needed to be removed simultaneously
• During the operation, other intrahepatic lesions were discovered, which required combination with other surgeries, such as ablation or choledochojejunostomy
• Diseases that have previously received systemic treatment with glucocorticoids, such as chronic kidney disease, inflammatory diseases, or other immune system-related disorders
• Psychosis, severe neurosis, those who cannot cooperate with this experiment
• Participated in other clinical trials within the previous 3 months before enrollment
• Allergy or intolerance to benzoic acid, or to the study drug
• Pregnant and lactating women
• The researchers believe that any participants who have any other factors that would make them unsuitable for this trial should not be included