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NCT Number: NCT06346665

The Transplant Cohort of the German Center for Infection Research

Medical data and biological samples obtained from transplant patients are collected and managed across Germany with the help of the DZIF Transplant Cohort. The data and samples form the basis of scientific studies which investigate the connections between numerous factors influencing an organ's susceptibility to infection and organ function.

Recruiting

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Key information

Conditions

Infections Immunosuppression Transplant Complication Transplant Failure

Sex eligibility

All sexes

Study type

Observational

Primary location

Technische Universität München

München, Germany

Location status: Recruiting

Location contact

Daniela Schindle, Dr.

CONTACT

About this study

Infections in transplant recipients have a decisive impact on graft function and survival of the transplant recipient, but many issues are still poorly understood. For example, little is known about the long-term consequences of many infections on graft survival/function and graft- versus-host disease (GvHD), the role of individual susceptibility to bacterial, viral and fungal colonisation under immune suppression, the evolution of the antiviral T cell repertoire, the long- term impact of antiviral therapy on graft and patient survival or changes in the physiological microbiome that may have a bearing on colonisation with pathogenic microbes. Taking advantage of the fact that most of the university hospitals with sizeable transplantation programs in Germany are also DZIF partners, we will establish a large multicentre prospective observational cohort of transplant recipients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Consent
  • undergone transplantation of kidney, pancreas, liver, heart or stem cells

Exclusion criteria

  • No consent

Treatment and study plan

Primary outcomes

  1. Realisation of studies that focus on the the medical needs of transplant patients, particularly with regard to their susceptibility to infection

    Time frame: 10 years

    Provision of collected data and biosamples to research groups for the realisation of scientific studies with a number of resources that individual clinics could not provide on their own

Study contacts

Contact information is provided by the study sponsor or research team.

Daniela Schindler, Dr.

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Collaborators

  • Hannover Medical School
  • Helmholtz Centre for Infection Research
  • Klinikum der Universität München
  • Max von Pettenkofer-Institut München
  • Nierenzentrum Heidelberg
  • University Hospital Heidelberg
  • Universität Tübingen

Registry information

Important dates

Study start
2016
Primary completion
2025
Study completion
2030
First posted
Apr 4, 2024
Registry last updated
Apr 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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